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Not only did the number of animals used in experiments increase dramatically in this period, but also the variety of species, as well as the purposes for which animals were used. However, from the 1970s onwards, the number of animal experiments has decreased. The reasons for this decrease are briefly explored.<\/jats:p>","DOI":"10.1177\/00236772261435373","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:57:07Z","timestamp":1782284227000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of animal use in experiments: a brief historical overview"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-1530","authenticated-orcid":false,"given":"Vera","family":"Baumans","sequence":"first","affiliation":[{"name":"Division Animals in Science and Society, Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-5167","authenticated-orcid":false,"given":"Mangala","family":"Gunatilake","sequence":"additional","affiliation":[{"name":"Department of Physiology and 3Rs Centre in Laboratory Animal Science, Faculty of Medicine, University of Colombo, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0505-9824","authenticated-orcid":false,"given":"Ensari","family":"Guneli","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey"},{"name":"Izmir Biomedicine and Genome Center, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8711-3732","authenticated-orcid":false,"given":"Bert","family":"Van Zutphen","sequence":"additional","affiliation":[{"name":"Em Professor, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"201","article-title":"A brief history of animal modeling","volume":"110","author":"Ericsson AC","year":"2013","unstructured":"Ericsson AC, Crim MJ, Franklin CL. 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