{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:03:58Z","timestamp":1784246638527,"version":"3.55.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lab Anim"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Magnesium regulates myocardial depolarisation, vascular tone, neuromuscular function and provides analgesia. This study examined its analgesic and haemodynamic effects, comparing the effects of intravenous saline 0.9% (NaCl; control\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20098) and magnesium (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20097) infusions in minipigs undergoing thoracotomy. Preoperative single-housed activity was recorded for 1 h. Intraoperatively, arterial blood pressure (BP) and heart rate (HR) were recorded once telemetry was established; data from the final 60\u2009min of anaesthesia were compared between groups. Postoperative activity, HR and BP were recorded continuously using in-pen CCTV and telemetry, respectively. Indicators of pain, including HR and BP were sampled after tracheal extubation (T\n                    <jats:sub>TE<\/jats:sub>\n                    ) at +0.5, +2.5, +4.5, +6, +8.5, +15.5, +17.5, +19.5, +20, +23, +25.5, +26 and +29\u2009h. Changes in HR and BP before and after analgesia at T\n                    <jats:sub>TE<\/jats:sub>\n                    +6, +17.5, +23 and +29\u2009h, and pre- and post-pain assessments at T\n                    <jats:sub>TE<\/jats:sub>\n                    +2.5, +6, +17.5, +20, +23, +26 and +29\u2009h were compared using a paired\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    -test. During anaesthesia, no electrocardiography derangements were noted. There was no difference between groups in the area under the curve for any cardiovascular variable. Magnesium-treated animals had an increased incidence of hypotension during anaesthesia. Postoperatively, activity decreased significantly for both groups for duration (all time points) and frequency (T\n                    <jats:sub>TE<\/jats:sub>\n                    +0.5, +4.5, +8.5, +15.5\u2009h), but no treatment effect was observed. Pain scores were comparable between groups. Following pain assessment and analgesia administration at T\n                    <jats:sub>TE<\/jats:sub>\n                    +17.5, Group NaCl had significant increases in HR and mean arterial pressure The magnesium dose evaluated produced no harm nor obvious benefit.\n                  <\/jats:p>","DOI":"10.1177\/00236772261441113","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:00:51Z","timestamp":1781186451000},"page":"280-293","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The effects of magnesium infusions on haemodynamic and nociceptive variables in minipigs undergoing thoracotomy"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6811-690X","authenticated-orcid":false,"given":"Bryony","family":"Few","sequence":"first","affiliation":[{"name":"Charles River Laboratories, Tranent, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1663-2689","authenticated-orcid":false,"given":"Scott","family":"Burgess","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Tranent, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-0158","authenticated-orcid":false,"given":"Matt","family":"Leach","sequence":"additional","affiliation":[{"name":"Newcastle University, Newcastle Upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-7755","authenticated-orcid":false,"given":"R. 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