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Here, we describe a practical protocol for the housing of spiny mice in large individually ventilated cages, including cage setup, diet, environmental enrichment, breeding, and health monitoring. We also provide recommendations for standard procedures used in animal research, such as identification methods, anesthesia, analgesia, and euthanasia. Last, we expand on the best laboratory practices in the context of common surgical procedures used in the field of regenerative biology, such as dorsal skin wounds and ear punch injury. Our recommendations are based on a decade of experience with routine colony management and behavioral observations at different European research sites and are intended as a practical reference for laboratories starting up\n                    <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                    colonies and as guidelines for regulatory authorities and ethics committees involved in approval processes for\n                    <jats:italic toggle=\"yes\">Acomys<\/jats:italic>\n                    facilities and research.\n                  <\/jats:p>","DOI":"10.1177\/00236772261458186","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:25:57Z","timestamp":1784967957000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Species-specific housing and routine procedures for spiny mice (\n                    <i>Acomys<\/i>\n                    ) maintained in large individually ventilated cages"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-1969","authenticated-orcid":false,"given":"Antonio","family":"Tomasso","sequence":"first","affiliation":[{"name":"Stanford University, School of Medicine, Department of Surgery, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-2639","authenticated-orcid":false,"given":"Aida","family":"Rodrigo Albors","sequence":"additional","affiliation":[{"name":"Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, UK"},{"name":"Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7776-287X","authenticated-orcid":false,"given":"Sofia","family":"Ferreira-Gonzalez","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research, 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Bobadilla","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Cell and Molecular Biology, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5935-0211","authenticated-orcid":false,"given":"Sebastian A.","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1841-5330","authenticated-orcid":false,"given":"Gustavo","family":"Tiscornia","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR\/CIMAR LA), Campus de Gambelas, Universidade do Algarve, Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-1989","authenticated-orcid":false,"given":"Sofia","family":"Lamas","sequence":"additional","affiliation":[{"name":"i3S, 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