{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:15:46Z","timestamp":1783703746049,"version":"3.55.0"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Linacre Q"],"abstract":"<jats:p>In vitro gametogenesis (IVG) represents a paradigm shift in assisted reproductive technologies (ART) by offering the potential to derive human sperm and eggs from somatic cells such as skin fibroblasts. This introduces profound ethical, legal, and social challenges. This article explores Catholic bioethics perspectives on IVG, evaluating its proposed applications against foundational theological principles, including the sanctity of life, the nature of marriage, and the dignity of procreation. It examines the use of IVG for addressing primary and age-related infertility, facilitating transgender and intersex parenthood, and preventing the transmission of genetic diseases. Furthermore, it critically assesses more controversial applications, such as posthumous reproduction; mass production of donor gametes; same-sex, solo, and multiplex parenthood; and the genetic enhancement of offspring. Drawing upon Catholic moral frameworks, the analysis highlights the tension between the therapeutic desire to alleviate infertility and the ethical imperative to uphold the natural order of reproduction. The article concludes that while IVG may offer novel solutions for certain reproductive challenges, its broader applications risk commodifying human life, fracturing traditional family structures, and advancing eugenic ideologies, necessitating robust ethical reflection and regulatory oversight.<\/jats:p>","DOI":"10.1177\/00243639261462805","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:20:56Z","timestamp":1783434056000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Catholic Bioethics Perspectives on In Vitro Gametogenesis Technology"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3547-5271","authenticated-orcid":false,"given":"Alexis Heng Boon","family":"Chin","sequence":"first","affiliation":[{"name":"Singapore Fertility Consultancy Pvt Ltd., Chinatown, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-7243","authenticated-orcid":false,"suffix":"III","given":"Teofilo Giovan S.","family":"Pugeda","sequence":"additional","affiliation":[{"name":"Department of Theology, Ateneo de Manila University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_3_3_2_1","volume-title":"Catechism of the Catholic Church","year":"1997","unstructured":"Catechism of the Catholic Church. 1997. 2nd ed. Washington, DC: United States Catholic Conference.","edition":"2"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202400106"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/frspt.2025.1539106"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03351338"},{"key":"e_1_3_3_6_1","unstructured":"Burbidge M. F. 2025. \u201cThe Christian Family In Vitro Fertilization and Heroic Witness to True Love.\u201d Catholic Diocese of Arlington. Accessed May 29 2026. https:\/\/www.arlingtondiocese.org\/2025\/01\/22\/the-christian-family-in-vitro-fertilization-and-heroic-witness-to-true-love\/."},{"key":"e_1_3_3_7_1","unstructured":"Chia R. 2018. \u201cIn-Vitro Gametogenesis.\u201d ETHOS Institute for Public Christianity June 1. Accessed May 29 2026. https:\/\/ethosinstitute.sg\/in-vitro-gametogenesis\/."},{"key":"e_1_3_3_8_1","article-title":"Ethical, Legal and Social Issues in Utilizing In Vitro Gametogenesis (IVG) and Stem Cell-Based Embryo Models (SCBEMs) for Human Reproduction in Singapore.","author":"Chin A. H. B.","unstructured":"Chin A. H. B., Alon I., Weerasekera T. A., Bosenge-Nguma J. D., Sun H.. 2025a. \u201cEthical, Legal and Social Issues in Utilizing In Vitro Gametogenesis (IVG) and Stem Cell-Based Embryo Models (SCBEMs) for Human Reproduction in Singapore.\u201d Health Care Analysis, https:\/\/doi.org\/10.1007\/s10728-025-00521-6.","journal-title":"Health Care Analysis"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-025-03713-0"},{"key":"e_1_3_3_10_1","unstructured":"Christian Medical & Dental Association (CMDA). 2025. \u201cPosition Statement on In Vitro Fertilization.\u201d Accessed May 29 2026. https:\/\/app.box.com\/s\/i0fm4d1d62lj709mav6v3wf2vsaxova5."},{"issue":"3","key":"e_1_3_3_11_1","first-page":"619","article-title":"A Balancing Act? The Rights of Donor-Conceived Children to Know Their Biological Origins.","volume":"40","author":"Clark B.","year":"2012","unstructured":"Clark B. 2012. \u201cA Balancing Act? The Rights of Donor-Conceived Children to Know Their Biological Origins.\u201d Georgia Journal of International and Comparative Law 40 (3): 619\u2013661. https:\/\/digitalcommons.law.uga.edu\/cgi\/viewcontent.cgi?httpsredir=1&article=1001&context=gjicl.","journal-title":"Georgia Journal of International and Comparative Law"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2025.02.024"},{"key":"e_1_3_3_13_1","unstructured":"Congregation for the Doctrine of the Faith. 1987. Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation: Donum Vitae. Libreria Editrice Vaticana. https:\/\/www.vatican.va\/roman_curia\/congregations\/cfaith\/documents\/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html."},{"key":"e_1_3_3_14_1","unstructured":"Congregation for the Doctrine of the Faith. 2008. Instruction Dignitas Personae on Certain Bioethical Questions. 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