{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:08:40Z","timestamp":1793120920474,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Omega (Westport)"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyse the available evidence regarding refractory symptoms to treatment in patients receiving palliative\/terminal healthcare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      A systematic review of various databases between September and December 2020; Pubmed; Cochrane; Scopus and ScienceDirect. Study eligibility criteria: Studies published between 1\n                      <jats:sup>st<\/jats:sup>\n                      January 2015 and 31\n                      <jats:sup>st<\/jats:sup>\n                      of March 2020, in Spanish, English or Catalan conducted in elderly people or terminal patients. The study included systematic reviews, clinical trials and interventions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The search returned 782 articles, of which 22 articles were finally reviewed. Of the selected articles, 16 were systematic reviews and three were clinical trials. Three refractory symptoms are notable; breathlessness, delirium and existential suffering. There are various therapeutic approaches for the first two symptoms, but palliative sedation seems to be most effective for existential suffering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although palliative care enables controlling these symptoms effectively, and following a multidisciplinary approach, there remains a group of patients for whom euthanasia could save foreseeable suffering that is difficult to manage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00302228221089123","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T06:46:47Z","timestamp":1650437207000},"page":"1113-1127","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Systematic Review of Common Refractory Symptoms in the End-Of-Life Situation and Its Relation With Euthanasia"],"prefix":"10.1177","volume":"89","author":[{"given":"Alba","family":"Lucena","sequence":"first","affiliation":[{"name":"Surgery Department, Faculty of Medicine, University of Lleida, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-8005","authenticated-orcid":false,"given":"Oriol","family":"Yuguero","sequence":"additional","affiliation":[{"name":"Surgery Department, Faculty of Medicine, University of Lleida, Lleida, Spain"},{"name":"Institut de Recerca Biom\u00e8dica de Lleida (IRBLLEIDA), Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"bibr1-00302228221089123","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2020.09.022"},{"issue":"104","key":"bibr2-00302228221089123","first-page":"23","volume":"32","author":"Aznar J.","year":"2021","journal-title":"Cuadernos De Bio\u00e9tica"},{"issue":"1","key":"bibr3-00302228221089123","first-page":"CD010206","volume":"1","author":"Beller E. 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