{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:39:47Z","timestamp":1792679987724,"version":"4.5.0"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Omega (Westport)"],"abstract":"<jats:p>\n                    Bereavement can adversely affect psychological and physical health. Using MIDUS Refresher 1 data, we examined psychological and inflammatory differences between bereaved (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 373) and non-bereaved (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 490) adults and tested whether depression, anxiety, and stress moderated associations between bereavement and inflammation. Participants completed measures of depressive symptoms, anxiety, and perceived stress and provided blood samples for interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-\u03b1), and C-reactive protein (CRP). Adjusting for key covariates, bereaved participants reported significantly greater depressive symptoms, anxiety, and perceived stress (\n                    <jats:italic toggle=\"yes\">ps<\/jats:italic>\n                    &lt; .001) and had higher IL-6 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = .001) and TNF-\u03b1 (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; .001) than non-bereaved participants. Psychological symptoms did not moderate associations between bereavement and inflammatory markers. Findings suggest that bereavement is associated with concurrent psychological distress and elevated inflammation, but these effects may be partly independent. Identifying other psychological and contextual factors may clarify individual differences in inflammatory responses following loss.\n                  <\/jats:p>","DOI":"10.1177\/00302228261500223","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:43:19Z","timestamp":1792492999000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bereavement, Psychological Distress, and Inflammation: Findings From the MIDUS Refresher Cohort"],"prefix":"10.1177","author":[{"given":"Kylee F.","family":"Behringer","sequence":"first","affiliation":[{"name":"School of Psychology, University of Southern Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-4270","authenticated-orcid":false,"given":"Megan E.","family":"Renna","sequence":"additional","affiliation":[{"name":"Department of Psychology, The Ohio State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"crossref","unstructured":"Abrams L. Mehta N. (2019). Changes in depressive symptoms over age among older Americans: Differences by gender race\/ethnicity education and birth cohort. SSM Population Health 7 Article 100399. J. 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F.","year":"2012","unstructured":"Hayes A. F. (2012). PROCESS: A versatile computational tool for observed variable mediation, moderation, and conditional process modeling. University of Kansas."},{"key":"e_1_3_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1531903100"},{"issue":"5","key":"e_1_3_7_18_1","first-page":"415","article-title":"A systematic review of the association between bereavement and biomarkers of immune function","volume":"81","author":"Knowles L. M.","year":"2019","unstructured":"Knowles L. M., Ruiz J. M., O'Connor M.-F. (2019). A systematic review of the association between bereavement and biomarkers of immune function. Biopsychosocial Science and Medicine, 81(5), 415\u2013433.","journal-title":"Biopsychosocial Science and Medicine"},{"key":"e_1_3_7_19_1","doi-asserted-by":"crossref","unstructured":"Komischke-Konnerup K. B. Zachariae R. Johannsen M. Nielsen L. D. O'Connor M. (2021). Co-occurrence of prolonged grief symptoms and symptoms of depression anxiety and posttraumatic stress in bereaved adults: A systematic review and meta-analysis. Journal of Affective Disorders Reports 4 Article 100140. https:\/\/doi.org\/10.1016\/j.jadr.2021.100140","DOI":"10.1016\/j.jadr.2021.100140"},{"issue":"1","key":"e_1_3_7_20_1","first-page":"2","article-title":"Emotion regulation and immune functioning during grief: Testing the role of expressive suppression and cognitive reappraisal in inflammation among recently bereaved spouses","volume":"82","author":"Lopez R. B.","year":"2020","unstructured":"Lopez R. B., Brown R. L., Wu E.-L. L., Murdock K. W., Denny B. T., Heijnen C., Fagundes C. (2020). Emotion regulation and immune functioning during grief: Testing the role of expressive suppression and cognitive reappraisal in inflammation among recently bereaved spouses. 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