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Online computer databases PubMed, PsycINFO and Web of Science were searched systematically and thoroughly. Jamovi 1.8.1 Current version was used to conduct meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty studies were included in the review, and 14 of these, including 2257 subjects, were used for meta-analysis. The raw correlation ranged from 0.17 to 0.58, which indicated weak to moderate association between negative affects and craving. In total, approximately 90% of the selection revealed a positive correlation between negative affects and craving. Alcohol and tobacco use disorders have received the most attention. Additionally, negative affectivity was often defined as a transient state rather than a stable personality trait.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In both of our meta-analyses and in the narratively reported studies, we found that negative affectivity is an important component related to craving, but individual differences in craving reactivity existed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00332941211061079","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T20:22:45Z","timestamp":1643746965000},"page":"1143-1180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Association Between Negative Affectivity and Craving in Substance-Related Disorders: A Systematic Review and Meta-analysis of Direct and Indirect Relationships"],"prefix":"10.1177","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7014-5123","authenticated-orcid":false,"given":"Laura","family":"Cyr","sequence":"first","affiliation":[{"name":"LPCPP, Aix Marseille University, Aix-en-Provence, France; Clinique Saint-Barnab\u00e9, Ramsay Sant\u00e9, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bernard","sequence":"additional","affiliation":[{"name":"LPCPP, Aix Marseille University, Aix-en-Provence, France; Clinique Saint-Barnab\u00e9, Ramsay Sant\u00e9, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Pedinielli","sequence":"additional","affiliation":[{"name":"LPCPP, Aix Marseille University, Aix-en-Provence, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Cutarella","sequence":"additional","affiliation":[{"name":"Clinique Saint-Barnab\u00e9, Ramsay Sant\u00e9, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1344-0489","authenticated-orcid":false,"given":"Vincent","family":"Br\u00e9jard","sequence":"additional","affiliation":[{"name":"LPCPP, Aix Marseille University, Aix-en-Provence, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"bibr1-00332941211061079","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X05282643"},{"key":"bibr2-00332941211061079","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2007.03.016"},{"key":"bibr3-00332941211061079","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7382.219"},{"key":"bibr4-00332941211061079","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"issue":"2","key":"bibr5-00332941211061079","first-page":"23","volume":"7","author":"Andersohn F.","year":"2004","journal-title":"German Journal of Psychiatry"},{"key":"bibr78-00332941211061079","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01475.x"},{"key":"bibr6-00332941211061079","doi-asserted-by":"publisher","DOI":"10.1016\/j.amp.2018.08.014"},{"key":"bibr7-00332941211061079","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.111.1.33"},{"key":"bibr79-00332941211061079","doi-asserted-by":"crossref","unstructured":"Beck A. 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