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The present paper introduces the Transformational Clinical Matrix-Expanded (TCM-XP), a transdiagnostic and metatheoretical framework developed to organize these processes within a developmental and integrative perspective. The TCM-XP comprises seven interrelated domains: Adverse and Dysfunctional Experiences, Emotional Wounds, Dialectical Core Schemas, Affective Dysregulation, Coping and Dispositional Responses, Maladaptive Patterns, and Complex Neural Network Dysfunctions. These domains are proposed to operate recursively rather than independently, suggesting that adverse relational and contextual experiences may contribute to the frustration of core biopsychosocial pressures, affectively encoded emotional wounds, polarized cognitive-affective representations, affective dysregulation, and recurrent coping and interpersonal patterns. The model also considers the possible contribution of large-scale brain networks and related neurobiological systems without reducing psychological functioning to neural mechanisms. By integrating developmental psychopathology, trauma theory, clinical psychology, personality perspectives, and affective neuroscience, TCM-XP provides a conceptual organization of complex psychological functioning that may inform assessment, case conceptualization, and clinical decision-making.<\/jats:p>","DOI":"10.1177\/00332941261481769","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:01:10Z","timestamp":1788883270000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Transformational Clinical Matrix-Expanded: Metatheoretical Framework for Conceptualizing Dysfunctional Processes and Psychopathology"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-1622","authenticated-orcid":false,"given":"Bruno","family":"Faustino","sequence":"first","affiliation":[{"name":"School of Psychology and Health Sciences, Lus\u00f3fona University, Lisbon, Portugal"},{"name":"HEI-Lab: Digital Human-Environment Interaction Lab, Lus\u00f3fona University, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_3_5_2_1","volume-title":"Patterns of attachment: A psychological study of the strange situation","author":"Ainsworth M. 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