{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:39:47Z","timestamp":1790066387068,"version":"4.0.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Rep"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>This study examined the methodology of observational studies that explored an association between personal use of hair dye products and the risk of bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Data were pooled from epidemiological studies using a general variance-based meta-analytic method that employed confidence intervals. The outcome of interest was a summary relative risk (RRs) reflecting the risk of bladder cancer development associated with use of hair dye products vs. non-use. Sensitivity analyses were performed to explain any observed statistical heterogeneity and to explore the influence of specific study characteristics of the summary estimate of effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Initially combining homogenous data from six case-control and one cohort study yielded a non-significant RR of 1.01 (0.92, 1.11), suggesting no association between hair dye use and bladder cancer development. Sensitivity analyses examining the influence of hair dye type, color, and study design on this suspected association showed that uncontrolled confounding and design limitations contributed to a spurious non-significant summary RR. The sensitivity analyses yielded statistically significant RRs ranging from 1.22 (1.11, 1.51) to 1.50 (1.30, 1.98), indicating that personal use of hair dye products increases bladder cancer risk by 22% to 50% vs. non-use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>The available epidemiological data suggest an association between personal use of hair dye products and increased risk of bladder cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/003335490512000107","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T09:01:34Z","timestamp":1485421294000},"page":"31-38","source":"Crossref","is-referenced-by-count":52,"title":["Personal Use of Hair Dyes and the Risk of Bladder Cancer: Results of a Meta-Analysis"],"prefix":"10.1177","volume":"120","author":[{"given":"Michael","family":"Huncharek","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Department of Clinical Oncology, Marshfield Clinic Cancer Center, Marshfield, WI; Meta-Analysis Research Group, Stevens Point, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Kupelnick","sequence":"additional","affiliation":[{"name":"Meta-Analysis Research Group, Stevens Point, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"bibr1-003335490512000107","first-page":"8","volume":"45","author":"Wingo PA","year":"1995","journal-title":"American Cancer Society"},{"key":"bibr2-003335490512000107","volume-title":"SEER cancer statistics review 1973\u20131990","author":"Hankey BF","year":"1993"},{"key":"bibr3-003335490512000107","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199502000-00003"},{"key":"bibr4-003335490512000107","doi-asserted-by":"publisher","DOI":"10.1016\/0273-2300(81)90084-2"},{"key":"bibr5-003335490512000107","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.6.2423"},{"key":"bibr6-003335490512000107","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(68)90106-3"},{"key":"bibr7-003335490512000107","unstructured":"Petitti DB. Meta-analysis, decision analysis and cost-effectiveness analysis. Methods for quantitative synthesis in medicine, 2nd ed. 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