{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:39:33Z","timestamp":1777898373817,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Rep"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives.<\/jats:title>\n                    <jats:p>Hepatitis C, an important cause of premature mortality, is the most common chronic bloodborne infection in the United States. The severity of disease is strongly affected by a number of other medical conditions and health behaviors. We sought to estimate the association of several exposures with hepatitis C on death certificates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>We enrolled 63,189 hepatitis C deaths as cases in a case-control study using multiple-cause-of-death data for the U.S. from 1999 to 2004. Three control groups were assembled from all remaining deaths with no mention of hepatitis C, including a random sample of all deaths, digestive disease deaths, and circulatory disease deaths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Hepatitis B, human immunodeficiency virus (HIV), hemochromatosis, and alcohol use were all strongly associated with hepatitis C, even after controlling for confounding variables. The simultaneous presence of many of these exposures had a synergistic association with hepatitis C being listed as a cause of death. Hepatitis B, HIV, and alcohol use were recorded among 6.4%, 10.5%, and 18.2% of case deaths, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>The strong association of alcohol use, HIV, and hepatitis B with hepatitis C, as well as the frequent occurrence of these conditions, indicates that targeted interventions for mitigating the potential effect of these exposures may present an efficient means of limiting progression of hepatitis C-related liver disease and reducing the population burden of hepatitis C mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/003335491012500310","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T07:10:56Z","timestamp":1485328256000},"page":"414-422","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic Factors Associated with Hepatitis C Disease: A Case-Control Study Utilizing U.S. Multiple-Cause-of-Death Data"],"prefix":"10.1177","volume":"125","author":[{"given":"Matthew","family":"Wise","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of California, Los Angeles, School of Public Health, Los Angeles, CA"},{"name":"Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn","family":"Finelli","sequence":"additional","affiliation":[{"name":"Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Sorvillo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of California, Los Angeles, School of Public Health, Los Angeles, CA"},{"name":"Office of Health Assessment and Epidemiology, Los Angeles Department of Public Health, Los Angeles, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,5,1]]},"reference":[{"key":"bibr1-003335491012500310","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00004"},{"issue":"19","key":"bibr2-003335491012500310","first-page":"1","volume":"47","year":"1998","journal-title":"MMWR Recomm Rep"},{"key":"bibr3-003335491012500310","volume-title":"Annual report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant data 1995\u20132004","author":"Department of Health and Human Services (US)","year":"2005"},{"key":"bibr4-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22165"},{"key":"bibr5-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310332"},{"key":"bibr6-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07642-8"},{"key":"bibr7-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200105000-00007"},{"key":"bibr8-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06102-5"},{"key":"bibr9-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1086\/321909"},{"key":"bibr10-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0080-0"},{"key":"bibr11-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1177\/095646240401500502"},{"key":"bibr12-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00531.x"},{"key":"bibr13-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00407-6"},{"key":"bibr14-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3180381584"},{"key":"bibr15-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310325"},{"key":"bibr16-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04759.x"},{"key":"bibr17-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2042"},{"key":"bibr18-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1086\/323896"},{"key":"bibr19-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1086\/345906"},{"key":"bibr20-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80198-0"},{"key":"bibr21-003335491012500310","first-page":"1404","volume":"44","author":"Ael S Mohamed","year":"1997","journal-title":"Hepatogastroenterology"},{"key":"bibr22-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70233-6"},{"key":"bibr23-003335491012500310","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114375"},{"key":"bibr24-003335491012500310","unstructured":"National Center for Health Statistics. 2003 revision of the U.S. Standard Death Certificate [cited 2008 Dec 1]. 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