{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T08:42:23Z","timestamp":1792744943186,"version":"4.5.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Rep"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Severe combined immunodeficiency (SCID) is the result of genetic defects that impair normal T-cell development. SCID babies typically appear normal at birth, but acquire multiple life-threatening infections within a few months. Early diagnosis and treatment with a bone-marrow transplant markedly improves long-term outcomes.<\/jats:p>\n                  <jats:p>On January 1, 2008, the newborn screening (NBS) program in Wisconsin became the first in the world to routinely test all newborns for SCID. A realtime quantitative polymerase chain reaction assay measures T-cell receptor excision circles (TRECs), which are formed during the maturation of normal T-cells. A lack or very low number of TRECs is consistent with T-cell lymphopenia. The development and validation of the TREC assay and the results of the first year of screening have been published. This article describes the process used to add SCID to the NBS panel, the establishment of follow-up capacity, and the integration of SCID screening into routine NBS workflows. The development of this expanded NBS program is described so that other states might benefit from the processes used in Wisconsin.<\/jats:p>","DOI":"10.1177\/00333549101250s211","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T14:48:07Z","timestamp":1499179687000},"page":"88-95","source":"Crossref","is-referenced-by-count":56,"title":["Implementing Routine Testing for Severe Combined Immunodeficiency within Wisconsin's Newborn Screening Program"],"prefix":"10.1177","volume":"125","author":[{"given":"Mei Wang","family":"Baker","sequence":"first","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald H.","family":"Laessig","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray L.","family":"Katcher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Wisconsin Department of Health Services, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Routes","sequence":"additional","affiliation":[{"name":"Division of Allergy\/Clinical Immunology, Department of Pediatrics, Medical College of Wisconsin\/Children's Research Institute, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Grossman","sequence":"additional","affiliation":[{"name":"Division of Allergy\/Clinical Immunology, Department of Pediatrics, Medical College of Wisconsin\/Children's Research Institute, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Verbsky","sequence":"additional","affiliation":[{"name":"Division of Allergy\/Clinical Immunology, Department of Pediatrics, Medical College of Wisconsin\/Children's Research Institute, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Kurtycz","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Brokopp","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,5,1]]},"reference":[{"key":"bibr1-00333549101250S211","unstructured":"Baker M, Brokopp C, Hoffman G, Laessig R, Kurtycz D, Grossman W, Newborn screening for severe combined immunodeficiencies (SCID)\u2014a 2008 Wisconsin perspective. Proceedings of the 2008 Newborn Screening and Genetic Testing Symposium; 2008 Nov 3\u20136; San Antonio. Silver Spring (MD): Association of Public Health Laboratories; 2008."},{"key":"bibr2-00333549101250S211","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104614"},{"key":"bibr3-00333549101250S211","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282f14a2a"},{"key":"bibr4-00333549101250S211","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.053"},{"key":"bibr5-00333549101250S211","volume-title":"Principles and practice of screening for disease","author":"Wilson JMG","year":"1968"},{"key":"bibr6-00333549101250S211","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/01.gim.0000223891.82390.ad","volume":"8","year":"2006","journal-title":"Genet Med"},{"key":"bibr7-00333549101250S211","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02293-5"},{"key":"bibr8-00333549101250S211","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.10.012"},{"key":"bibr9-00333549101250S211","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.04.007"},{"key":"bibr10-00333549101250S211","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1806"},{"key":"bibr11-00333549101250S211","unstructured":"Wisconsin Administrative Code, Department of Health Services. Criteria for adding or deleting conditions (DHS 115.06) (revised) (2009)."},{"key":"bibr12-00333549101250S211","unstructured":"Katcher ML, Brokopp CD. Wisconsin first state to screen all newborns for \u201cbubble boy disease.\u201d WMJ 2008; 107:113."},{"key":"bibr13-00333549101250S211","unstructured":"Health Resources and Services Administration (US). Advisory Committee on Heritable Disorders and Genetic Diseases in Newborns and Children [cited 2009 Nov 20]. Available from: URL: http:\/\/www.hrsa.gov\/heritabledisorderscommittee"},{"key":"bibr14-00333549101250S211","unstructured":"Lipstein E, Knapp AA, Perrin JM. Evidence review: Severe combined immunodeficiency (SCID) [cited 2009 Nov 20]. Available from: URL: Ftp:\/\/ftp.hrsa.gov\/mchb\/genetics\/reports\/SCIDevidencereviewfinal.pdf"},{"key":"bibr15-00333549101250S211","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00646.x"}],"container-title":["Public Health Reports\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00333549101250S211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00333549101250S211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:29:06Z","timestamp":1777627746000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00333549101250S211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":15,"journal-issue":{"issue":"2_suppl","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1177\/00333549101250S211"],"URL":"https:\/\/doi.org\/10.1177\/00333549101250s211","relation":{},"ISSN":["0033-3549","1468-2877"],"issn-type":[{"value":"0033-3549","type":"print"},{"value":"1468-2877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}