{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:40:42Z","timestamp":1778550042006,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01-HL-137557"],"award-info":[{"award-number":["K01-HL-137557"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Public Health Rep"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Daily tenofovir disoproxil fumarate\/emtricitabine (TDF\/FTC) use as HIV preexposure prophylaxis (PrEP) is monitored by identifying TDF\/FTC prescriptions from pharmacy databases and applying diagnosis codes and antiretroviral data to algorithms that exclude TDF\/FTC prescribed for HIV postexposure prophylaxis (PEP), HIV treatment, and hepatitis B virus (HBV) treatment. We evaluated the accuracy of 3 algorithms used by the Centers for Disease Control and Prevention (CDC), Gilead Sciences, and the New York State Department of Health (NYSDOH) using a reference population in Bronx, New York.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We extracted diagnosis codes and data on all antiretroviral prescriptions other than TDF\/FTC from an electronic health record database for persons aged \u226516 prescribed TDF\/FTC during July 2016\u2013June 2018\u2009at Montefiore Medical Center. We reviewed medical records to classify the true indication of first TDF\/FTC use as PrEP, PEP, HIV treatment, or HBV treatment. We applied each algorithm to the reference population and compared the results with the medical record review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 2862 patients included in the analysis, 694 used PrEP, 748 used PEP, 1407 received HIV treatment, and 13 received HBV treatment. The algorithms had high specificity (range: 98.4%-99.0%), but the sensitivity of the CDC algorithm using a PEP definition of TDF\/FTC prescriptions \u226430 days was lower (80.3%) than the sensitivity of the algorithms developed by Gilead Sciences (94.7%) or NYSDOH (96.1%). Defining PEP as TDF\/FTC prescriptions \u226428 days improved CDC algorithm performance (sensitivity, 95.8%; specificity, 98.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Adopting the definition of PEP as \u226428 days of TDF\/FTC in the CDC algorithm should improve the accuracy of national PrEP surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0033354920904085","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T15:40:00Z","timestamp":1581003600000},"page":"202-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Evaluation of Algorithms Used for PrEP Surveillance Using a Reference Population From New York City, July 2016\u2013June 2018"],"prefix":"10.1177","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-0556","authenticated-orcid":false,"given":"Nathan W.","family":"Furukawa","sequence":"first","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"},{"name":"Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"AIDS Institute, New York State Department of Health, Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Lin A.","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uriel R.","family":"Felsen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Montefiore Health System\/Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of HIV\/AIDS Prevention, National Center for HIV\/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia H.","family":"Arnsten","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, Montefiore Health System\/Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viraj V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, Montefiore Health System\/Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"bibr1-0033354920904085","unstructured":"US Public Health Service. Preexposure prophylaxis for the prevention of HIV infection in the United States\u20142017 update: clinical practice guidelines. https:\/\/www.cdc.gov\/hiv\/pdf\/risk\/prep\/cdc-hiv-prep-guidelines-2017.pdf. Published 2018. Accessed December 19, 2019."},{"key":"bibr2-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"bibr3-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108524"},{"key":"bibr4-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110711"},{"key":"bibr5-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61127-7"},{"key":"bibr6-0033354920904085","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6741a3"},{"key":"bibr7-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.05.003"},{"key":"bibr8-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.06.009"},{"key":"bibr9-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202806"},{"key":"bibr10-0033354920904085","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2018.304641"},{"key":"bibr11-0033354920904085","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2082"},{"key":"bibr12-0033354920904085","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2018.304471"},{"key":"bibr13-0033354920904085","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2018.304788"},{"key":"bibr14-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy230"},{"key":"bibr15-0033354920904085","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6446a5"},{"key":"bibr16-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw701"},{"key":"bibr17-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.06.005"},{"key":"bibr18-0033354920904085","unstructured":"Centers for Disease Control and Prevention. Updated guidelines for antiretroviral postexposure prophylaxis after sexual, injection drug use, or other nonoccupational exposure to HIV\u2014United States. 2016. https:\/\/www.cdc.gov\/hiv\/pdf\/programresources\/cdc-hiv-npep-guidelines.pdf. Accessed December 19, 2019."},{"key":"bibr19-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-016-1663-8"},{"key":"bibr20-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2014.911813"},{"key":"bibr21-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2015.0345"},{"key":"bibr22-0033354920904085","unstructured":"SAS\n                      [computer software]. Version 9.4. Cary, NC: SAS Institute, Inc; 2014."},{"key":"bibr23-0033354920904085","unstructured":"Centers for Disease Control and Prevention. Division of HIV\/AIDS Prevention strategic plan 2017-2020. https:\/\/www.cdc.gov\/hiv\/pdf\/dhap\/cdc-hiv-dhap-external-strategic-plan.pdf. Published 2016. Accessed December 30, 2018."},{"key":"bibr24-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1804306"},{"key":"bibr25-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ094"},{"key":"bibr26-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506273"},{"key":"bibr27-0033354920904085","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30089-9"},{"key":"bibr28-0033354920904085","unstructured":"Gilead Sciences. Safety and efficacy of emtricitabine and tenofovir alafenamide (F\/TAF) fixed-dose combination once daily for pre-exposure prophylaxis in men and transgender women who have sex with men and are at risk of HIV-1 infection (DISCOVER). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02842086?term=f%2Ftaf. Published 2016. Accessed December 30, 2018."}],"container-title":["Public Health Reports\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0033354920904085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0033354920904085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0033354920904085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:35:55Z","timestamp":1777628155000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0033354920904085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,6]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1177\/0033354920904085"],"URL":"https:\/\/doi.org\/10.1177\/0033354920904085","relation":{},"ISSN":["0033-3549","1468-2877"],"issn-type":[{"value":"0033-3549","type":"print"},{"value":"1468-2877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,6]]}}}