{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:26:33Z","timestamp":1778336793488,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005217","name":"National Center for Injury Prevention and Control","doi-asserted-by":"publisher","award":["NU17CE924908"],"award-info":[{"award-number":["NU17CE924908"]}],"id":[{"id":"10.13039\/100005217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Public Health Rep"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Drug overdose deaths in Connecticut increasingly involve a growing number of fentanyl analogs and other novel nonfentanyl synthetic opioids (ie, novel synthetics). Current postmortem toxicology testing methods often lack the sophistication needed to detect these compounds. We examined how improved toxicology testing of fatal drug overdoses can determine the prevalence and rapidly evolving trends of novel synthetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2016 to June 2019, the Connecticut Office of the Chief Medical Examiner increased its scope of toxicology testing of suspected drug overdose deaths in Connecticut from basic to enhanced toxicology testing to detect novel synthetics. The toxicology laboratory also expanded its testing panels during this time. We analyzed toxicology results to identify and quantify the involvement of novel synthetics over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2016 to June 2019, 3204 drug overdose deaths received enhanced toxicology testing; novel synthetics were detected in 174 (5.4%) instances. Ten different novel synthetics were detected with 205 total occurrences. Of 174 overdose deaths with a novel synthetic detected, most had 1 (n = 146, 83.9%) or 2 (n = 26, 14.9%) novel synthetics detected, with a maximum of 4 novel synthetics detected. Para-fluorobutyrylfentanyl\/FIBF, furanylfentanyl, and U-47700 were most identified overall, but specific novel synthetics came in and out of prominence during the study period, and the variety of novel synthetics detected changed from year to year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Enhanced toxicology testing for drug overdose deaths is effective in detecting novel synthetics that are not identified through basic toxicology testing. Identifying emerging novel synthetics allows for a timely and focused response to potential drug outbreaks and illustrates the changing drug market.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00333549211042829","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T16:23:32Z","timestamp":1635870212000},"page":"80S-86S","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Improvements in Toxicology Testing to Identify Fentanyl Analogs and Other Novel Synthetic Opioids in Fatal Drug Overdoses, Connecticut, January 2016\u2013June 2019"],"prefix":"10.1177","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6384-4070","authenticated-orcid":false,"given":"Heather A.","family":"Clinton","sequence":"first","affiliation":[{"name":"Connecticut Department of Public Health, Hartford, CT, USA"},{"name":"Injury Prevention Center, Connecticut Children\u2019s Medical Center, Hartford, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shobha","family":"Thangada","sequence":"additional","affiliation":[{"name":"Connecticut Department of Public Health, Hartford, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Gill","sequence":"additional","affiliation":[{"name":"Connecticut Office of the Chief Medical Examiner, Farmington, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Mirizzi","sequence":"additional","affiliation":[{"name":"Connecticut Department of Public Health, Hartford, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan B.","family":"Logan","sequence":"additional","affiliation":[{"name":"Connecticut Department of Public Health, Hartford, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"bibr1-00333549211042829","unstructured":"Global Smart Programme.\n                      Global Smart Update: Fentanyl and Its Analogues\u201450 Years On\n                      . United Nations Office on Drugs and Crime; 2017. Accessed January 20, 2020. https:\/\/www.unodc.org\/documents\/scientific\/Global_SMART_Update_17_web.pdf"},{"key":"bibr2-00333549211042829","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6643e1"},{"key":"bibr3-00333549211042829","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00184"},{"key":"bibr4-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000324"},{"key":"bibr5-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.11.002"},{"key":"bibr6-00333549211042829","unstructured":"Connecticut Office of the Chief Medical Examiner. Connecticut accidental drug intoxication deaths. Published 2020. Accessed February 14, 2020. https:\/\/portal.ct.gov\/OCME\/Statistics"},{"issue":"9","key":"bibr7-00333549211042829","first-page":"709","volume":"40","author":"Mohr ALA.","year":"2016","journal-title":"J Anal Toxicol"},{"key":"bibr8-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.08.016"},{"key":"bibr9-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.01.045"},{"key":"bibr10-00333549211042829","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00654"},{"key":"bibr11-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bky035"},{"key":"bibr12-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.12953"},{"key":"bibr13-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2016.08.445"},{"key":"bibr14-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.10.016"},{"key":"bibr15-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2393"},{"key":"bibr16-00333549211042829","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6727a4"},{"key":"bibr17-00333549211042829","unstructured":"NMS Labs. Postmortem toxicology. Accessed January 6, 2020. https:\/\/www.nmslabs.com\/forensic-testing\/death-investigation\/postmortem-toxicology"},{"key":"bibr18-00333549211042829","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6910a4"},{"key":"bibr19-00333549211042829","unstructured":"Centers for Disease Control and Prevention. Rising numbers of deaths involving fentanyl and fentanyl analogs, including carfentanil, and increased usage and mixing with non-opioids. Health Alert Network CDCHAN-00413. July 11, 2018. Accessed February 26, 2020. https:\/\/emergency.cdc.gov\/han\/han00413.asp"},{"key":"bibr20-00333549211042829","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6834a2"},{"key":"bibr21-00333549211042829","unstructured":"US Department of Justice. The countdown: fentanyl analogues & the expiring emergency scheduling order. June 4, 2019. Accessed March 9, 2020. https:\/\/www.judiciary.senate.gov\/imo\/media\/doc\/Liskamm-Cherundolo Joint Testimony.pdf"},{"key":"bibr22-00333549211042829","unstructured":"Knierim PE. Tackling fentanyl: the China connection. September 6, 2018. Accessed March 9, 2020. https:\/\/www.dea.gov\/sites\/default\/files\/2018-09\/DEA Testimony - China and Fentanyl HFAC_0.pdf"},{"key":"bibr23-00333549211042829","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6905a2"},{"key":"bibr24-00333549211042829","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bky049"}],"container-title":["Public Health Reports\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00333549211042829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00333549211042829","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00333549211042829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:37:22Z","timestamp":1777628242000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00333549211042829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":24,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/00333549211042829"],"URL":"https:\/\/doi.org\/10.1177\/00333549211042829","relation":{},"ISSN":["0033-3549","1468-2877"],"issn-type":[{"value":"0033-3549","type":"print"},{"value":"1468-2877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]}}}