{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:44:43Z","timestamp":1777898683718,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Public Health Rep"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Incarcerated persons in the United States have a high burden of hepatitis C virus (HCV) infection. This study assessed the impact of a statewide effort in Vermont to treat HCV in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a retrospective, observational cohort study of all HCV-infected persons who were imprisoned in Vermont during the 19-month study period (December 2018\u2013June 2020). The cascade of care comprised opt-out HCV screening, full access to direct-acting antiviral treatment (without hepatic fibrosis-based treatment restrictions), HCV specialist involvement, and medication-assisted treatment for patients with opioid use disorder. The primary outcome was sustained virologic response at 12 weeks after treatment completion (SVR12).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study included 217 HCV-infected patients; the median age was 35 years (range, 18-73 years), 89% were male, 76% had opioid use disorder, 67% had a psychiatric comorbidity, and 9% had cirrhosis. Of the 217 patients, 98% had a liver fibrosis assessment, 59% started direct-acting antiviral treatment, 55% completed direct-acting antiviral treatment, and 51% achieved documented SVR12. Of the 129 HCV-infected persons who started direct-acting antiviral treatment, 92% completed therapy and 86% achieved documented SVR12. Psychiatric comorbidity was not significantly associated with achieving SVR12 (odds ratio = 0.67; 95% CI, 0.27-1.65; P = .38), nor was receiving medication-assisted treatment for patients with opioid use disorder (odds ratio = 1.45; 95% CI, 0.62-2.56; P = .45).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study reports the highest SVR12 rate achieved in a state incarcerated population to date. HCV treatment in incarcerated populations is a practical and efficacious strategy that should serve a foundational role in HCV elimination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00333549221077070","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T02:28:31Z","timestamp":1646879311000},"page":"265-272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Statewide Assessment of the Hepatitis C Virus Care Cascade for Incarcerated Persons in Vermont"],"prefix":"10.1177","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-1353","authenticated-orcid":false,"given":"Andrew J.","family":"Hale","sequence":"first","affiliation":[{"name":"University of Vermont Medical Center, Burlington, VT, USA"},{"name":"Larner College of Medicine, University of Vermont, Burlington, VT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Mathur","sequence":"additional","affiliation":[{"name":"Larner College of Medicine, University of Vermont, Burlington, VT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Dejace","sequence":"additional","affiliation":[{"name":"University of Vermont Medical Center, Burlington, VT, USA"},{"name":"Larner College of Medicine, University of Vermont, Burlington, VT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Lidofsky","sequence":"additional","affiliation":[{"name":"University of Vermont Medical Center, Burlington, VT, USA"},{"name":"Larner College of Medicine, University of Vermont, Burlington, VT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"bibr1-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27978"},{"key":"bibr2-00333549221077070","doi-asserted-by":"publisher","DOI":"10.24875\/AIDSRev.M17000006"},{"key":"bibr3-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1007\/s11524-008-9305-8"},{"key":"bibr4-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7085"},{"key":"bibr5-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1177\/0033354919874081"},{"key":"bibr6-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2006.051599"},{"key":"bibr7-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1177\/003335491412900213"},{"key":"bibr8-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1002\/cld.47"},{"key":"bibr9-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25770"},{"key":"bibr10-00333549221077070","doi-asserted-by":"publisher","DOI":"10.7326\/M13-1133"},{"key":"bibr11-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0201-x"},{"key":"bibr12-00333549221077070","doi-asserted-by":"publisher","DOI":"10.7326\/M15-0617"},{"key":"bibr13-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1177\/0033354918813089"},{"key":"bibr14-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa105"},{"key":"bibr15-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32326-2"},{"key":"bibr16-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1186\/s40352-017-0055-0"},{"key":"bibr17-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.039"},{"key":"bibr18-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12512"},{"key":"bibr19-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa263"},{"key":"bibr20-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100567"},{"key":"bibr21-00333549221077070","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20190068"},{"key":"bibr22-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa301"},{"key":"bibr23-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-018-0269-z"},{"key":"bibr24-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.014"},{"key":"bibr25-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1007\/s11524-015-9953-4"},{"key":"bibr26-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"bibr27-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"bibr28-00333549221077070","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1610570"},{"key":"bibr29-00333549221077070","unstructured":"American Association for the Study of Liver Diseases\u2013Infectious Diseases Society of America. 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