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We performed a literature search for articles that describe US populations, were published during 2005-2021, and summarized evidence of the prevalence of HCV infection in recent HIV clusters and outbreaks among PWID. In population- and community-based studies, HCV antibody prevalence among PWID with HIV ranged from 10.7% to 71.4%, depending on the setting and study design. HCV\u2013HIV coinfection ranged from 70% to 94% among 5 larger HIV clusters or outbreaks among PWID during 2014-2021; where characterized, HCV diagnosis preceded HIV detection by a median of 4 to 5 years. Robust modernized surveillance is needed to support and measure the progress of city, state, and national activities for ending the HIV epidemic and eliminating hepatitis C. Developing and leveraging surveillance systems can identify missed opportunities for prevention, evaluate care, and build capacity for outbreak investigation. In addition, improved data on injection drug use are crucial to inform efforts for improved HCV and HIV testing, prevention, and treatment in settings that serve PWID. By providing data in a wholistic, integrated manner, public health surveillance programs can support efforts to overcome inefficiencies of disease-specific silos, accelerate delivery of preventive and clinical services, and address the excess disease burden and health disparities associated with HCV\u2013HIV coinfection.<\/jats:p>","DOI":"10.1177\/00333549231181348","type":"journal-article","created":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T05:21:38Z","timestamp":1690003298000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Hepatitis C Virus\u2013HIV Coinfection in the United States Among People Who Inject Drugs: Data Needed for Ending Dual Epidemics"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-2798","authenticated-orcid":false,"given":"Anne C.","family":"Moorman","sequence":"first","affiliation":[{"name":"Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3140-9530","authenticated-orcid":false,"given":"Danae","family":"Bixler","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyasu H.","family":"Teshale","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-1687","authenticated-orcid":false,"given":"Megan","family":"Hofmeister","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Chapin-Bardales","sequence":"additional","affiliation":[{"name":"Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,22]]},"reference":[{"key":"bibr1-00333549231181348","doi-asserted-by":"publisher","DOI":"10.1080\/17441692.2020.1724317"},{"key":"bibr2-00333549231181348","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac543"},{"key":"bibr3-00333549231181348","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097596"},{"key":"bibr4-00333549231181348","first-page":"1","volume":"426","author":"Hedegaard H","year":"2021","journal-title":"NCHS Data Brief"},{"key":"bibr5-00333549231181348","unstructured":"National Center for Health Statistics. 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