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We searched Google Scholar, PubMed, and SCOPUS for quantitative literature published from January 2003 through December 2022 in English from the United States and Canada. We excluded literature on vaccine-preventable diseases and HIV because these diseases were recently reviewed. Of the 250 articles that met inclusion criteria, more than half were on hepatitis C virus or Mycobacterium tuberculosis. Other articles were on COVID-19, respiratory syncytial virus, Staphylococcus aureus, group A Streptococcus, mpox (formerly monkeypox), 5 sexually transmitted infections, and gastrointestinal or vectorborne pathogens. Most studies showed higher prevalence, incidence, or measures of risk for infectious diseases among people experiencing homelessness as compared with people who are housed or the general population. Although having increased published data that quantify the infectious disease risks of homelessness is encouraging, many pathogens that are known to affect people globally who are not housed have not been evaluated in the United States or Canada. Future studies should focus on additional pathogens and factors leading to a disproportionately high incidence and prevalence of infectious diseases among people experiencing homelessness.<\/jats:p>","DOI":"10.1177\/00333549241228525","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T01:12:17Z","timestamp":1708477937000},"page":"532-548","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Infectious Diseases Among People Experiencing Homelessness: A Systematic Review of the Literature in the United States and Canada, 2003-2022"],"prefix":"10.1177","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-4920","authenticated-orcid":false,"given":"Caroline J.","family":"Waddell","sequence":"first","affiliation":[{"name":"Office of Readiness and Response, Centers for Disease Control and Prevention, Atlanta, GA, USA"},{"name":"Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos S.","family":"Saldana","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, School of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Schoonveld","sequence":"additional","affiliation":[{"name":"Office of Readiness and Response, Centers for Disease Control and Prevention, Atlanta, GA, USA"},{"name":"Oak Ridge Institute for Science and Education, US Department of Energy, Oak Ridge, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1406-0886","authenticated-orcid":false,"given":"Ashley A.","family":"Meehan","sequence":"additional","affiliation":[{"name":"Office of Readiness and Response, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina K.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay C.","family":"Butler","sequence":"additional","affiliation":[{"name":"Office of Readiness and Response, Centers for Disease Control and Prevention, Atlanta, GA, USA"},{"name":"Division of Infectious Disease, School of Medicine, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-9564","authenticated-orcid":false,"given":"Emily","family":"Mosites","sequence":"additional","affiliation":[{"name":"Office of Readiness and Response, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"bibr1-00333549241228525","unstructured":"US Department of Housing and Urban Development. 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