{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:45:47Z","timestamp":1777898747497,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2-3","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Public Health Rep"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The Laboratory Response Network (LRN) consists of US and international laboratories that respond to public health emergencies, such as biothreats. We used a qualitative approach to assess the successes and challenges of the LRN during the initial 10 weeks of the 2022 mpox outbreak (May 17\u2013July 31, 2022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted 9 unstructured interviews, which included 3 interviews with subject matter experts from the Centers for Disease Control and Prevention (CDC) and 6 interviews with state and local public health laboratories and epidemiologists and Association of Public Health Laboratories (APHL) staff. We asked guiding questions on investments in preparedness, successes, and challenges during the initial mpox response and asked for suggestions to improve future LRN responses to infectious disease outbreaks. We also reviewed data from 2 contemporaneous APHL surveys conducted in June and July 2022 in 84 LRN public health laboratories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Notable successes included availability of an assay that had received clearance from the US Food and Drug Administration (FDA) for testing orthopoxviruses (non-variola\n                      <jats:italic>Orthopoxvirus<\/jats:italic>\n                      [NVO] assay) and a trained workforce; strong relationships among FDA, CDC, and the LRN; and strong communications between LRN laboratories and CDC. Challenges included variability among LRN laboratories in self-reported testing capacity, barriers to accessing the NVO assay for health care providers, and gaps in LRN function during surges of testing needs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The LRN system plays an essential role in the response to emerging infectious disease outbreaks in the United States. Lessons learned from the LRN\u2019s initial response to the mpox outbreak can help guide improvements to better position the LRN for future responses, including continued engagement with health care providers, commercial laboratories, and laboratories in health care settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00333549241269497","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T04:47:30Z","timestamp":1724734050000},"page":"182-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Laboratory Response Network and Testing Access During the First 10 Weeks of the Mpox Response, United States, May 17\u2013July 31, 2022"],"prefix":"10.1177","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7000-0309","authenticated-orcid":false,"given":"Katharine L.","family":"Thomas","sequence":"first","affiliation":[{"name":"Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tricia A.","family":"Aden","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Blevins","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J.","family":"Raziano","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler","family":"Wolford","sequence":"additional","affiliation":[{"name":"Association of Public Health Laboratories, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Honein","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-4716","authenticated-orcid":false,"given":"Julie M.","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Readiness and Innovation, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. WHO recommends new name for monkeypox disease. April 17 2023. Accessed April 17 2023. https:\/\/www.who.int\/news\/item\/28-11-2022-who-recommends-new-name-for-monkeypox-disease"},{"key":"e_1_3_3_3_2","unstructured":"Centers for Disease Control and Prevention. Non-variola Orthopoxvirus and mpox virus laboratory testing data. Updated April 6 2023. Accessed April 17 2023. https:\/\/stacks.cdc.gov\/view\/cdc\/154063"},{"key":"e_1_3_3_4_2","unstructured":"Centers for Disease Control and Prevention. Technical Report 1: Multi-National Mpox Outbreak United States 2022. Updated January 6 2023. Accessed April 17 2023. https:\/\/www.cdc.gov\/poxvirus\/mpox\/cases-data\/technical-report\/report-1.html"},{"key":"e_1_3_3_5_2","unstructured":"Centers for Disease Control and Prevention. Ongoing 2022 global outbreak cases and data. Updated April 12 2023. Accessed April 17 2023. https:\/\/www.cdc.gov\/poxvirus\/mpox\/response\/2022\/index.html"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7128e1"},{"key":"e_1_3_3_7_2","unstructured":"US Food and Drug Administration. Medical device safety and the 510(k) clearance process. September 6 2023. Accessed May 20 2024. https:\/\/www.fda.gov\/medical-devices\/510k-clearances\/medical-device-safety-and-510k-clearance-process#:~:text=The%20510(k)%20clearance%20process%20involves%20a%20comprehensive%20review%20of"},{"key":"e_1_3_3_8_2","unstructured":"Centers for Disease Control and Prevention. Health Alert Network (HAN). November 15 2019. Accessed May 20 2024. https:\/\/emergency.cdc.gov\/han"},{"key":"e_1_3_3_9_2","unstructured":"Centers for Disease Control and Prevention. LRN-B enables a rapid laboratory response to biological threats. April 10 2019. Accessed April 17 2023. https:\/\/emergency.cdc.gov\/lrn\/lrnbfactsheet.asp"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0033354919874354"},{"key":"e_1_3_3_11_2","unstructured":"AdvanceTEC. BSL cleanroom specifications. 2023. Accessed April 17 2023. https:\/\/assets.website-files.com\/5c526262ffd5480e01efe071\/5f3d1b8366b32814bce151b5_AdvanceTEC%20-%20BSL%20Specifications%20PDF.pdf"},{"key":"e_1_3_3_12_2","unstructured":"Nunn S. Paperwork Reduction Act of 1995. 1995. Accessed May 19 2024. https:\/\/www.congress.gov\/bill\/104th-congress\/senate-bill\/244#:~:text=Requires%20each%20Federal%20agency%20to and%20equitable%20access%20to%20information"},{"key":"e_1_3_3_13_2","unstructured":"Penn M. Statistics say large pandemics are more likely than we thought. Duke Global Health Institute. August 23 2021. Accessed April 23 2023. https:\/\/globalhealth.duke.edu\/news\/statistics-say-large-pandemics-are-more-likely-we-thought"}],"container-title":["Public Health Reports\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00333549241269497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00333549241269497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00333549241269497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:39:51Z","timestamp":1777628391000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00333549241269497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":12,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/00333549241269497"],"URL":"https:\/\/doi.org\/10.1177\/00333549241269497","relation":{},"ISSN":["0033-3549","1468-2877"],"issn-type":[{"value":"0033-3549","type":"print"},{"value":"1468-2877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,27]]}}}