{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:25:59Z","timestamp":1787300759661,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000030","name":"centers for disease control and prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Public Health Rep"],"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Estimating the percentage of tuberculosis cases in a population attributable to recent transmission, compared with reactivation of past infections, is crucial for public health decision-making. This study evaluated a previously published plausible-source case (PSC) method for estimating recent transmission in Los Angeles County (LA County) against a reference standard based on epidemiologic and whole-genome sequencing data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed tuberculosis cases diagnosed in LA County from 2014 through 2018 using surveillance data. Cases were classified as consistent or inconsistent with recent transmission using the PSC method and a stepwise review of epidemiologic links and single nucleotide polymorphisms (Epi\/SNP). We compared classifications from both methods and assessed discrepancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 2949 tuberculosis cases in LA County, 650 had epidemiologic and whole-genome sequencing data for evaluating recent transmission; 44 were excluded due to missing genotyping data, including 7 pediatric patients aged &lt;15 years. The Epi\/SNP review classified 195 (30%) cases as consistent with recent transmission, while the PSC method attributed 301 (46%) cases to recent transmission. The 2 methods agreed on 454 (70%) cases. Discrepancies arose from genetic diversity, geographic distance, nonmatching genotypes, and diagnosis timing. Performance varied by race and ethnicity, nativity, lineage, history of homelessness, and substance use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The PSC method accurately classified more than two-thirds of tuberculosis cases included in a cluster investigation in LA County. However, findings underscore the need to refine the PSC method by integrating whole-genome sequencing data, including nongenotyped cases in pediatric patients, and reevaluating the geographic and timing criteria to enhance completeness and inform public health interventions aimed at interrupting tuberculosis transmission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00333549261468283","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:56:31Z","timestamp":1787028991000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Estimates of Recent Tuberculosis Transmission Using Epidemiologic and Whole-Genome Sequencing Data, Los Angeles County, California, 2014-2018"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-6758","authenticated-orcid":false,"given":"Clinton 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Tuberculosis Control Program, Los Angeles County Department of Public Health, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tambi","family":"Shaw","sequence":"additional","affiliation":[{"name":"Tuberculosis Control Branch, California Department of Public Health, Richmond, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Cilnis","sequence":"additional","affiliation":[{"name":"Tuberculosis Control Branch, California Department of Public Health, Richmond, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Noboa","sequence":"additional","affiliation":[{"name":"Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, USA"},{"name":"Tuberculosis Control Program, Los Angeles County Department 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