{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:43:27Z","timestamp":1777862607239,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1928,7,1]],"date-time":"1928-07-01T00:00:00Z","timestamp":-1309737600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proceedings of the Royal Society of Medicine"],"published-print":{"date-parts":[[1928,7]]},"abstract":"<jats:p>In the description of the condition of benign aplastic an\u00e6mia in pigs, attention is directed, among other things, to changes in the bone-marrow which seem of fundamental importance in understanding normal erythrogenesis.<\/jats:p>\n                  <jats:p>It is possible that an indirect van den Bergh reaction can be converted into an immediate direct by controlling the H-ion concentration suitably, either with buffer solutions or with less dissociable acids, such as acetic, used in preparing the van den Bergh reagent. The question of the interpretation of direct and indirect reactions, therefore, would seem to be reopened.<\/jats:p>\n                  <jats:p>Following Minot and Murphy's work, a pig with aplastic an\u00e6mia was fed with liver. The lesions in the liver, considered with the marked improvement in the blood which followed on liver feeding in this case, lead one to regard the condition as one of blood and marrow inefficiency due primarily to hepatic insufficiency.<\/jats:p>\n                  <jats:p>A comparison of pernicious an\u00e6mia with the benign aplastic an\u00e6mia of pigs seems to indicate that in pernicious an\u00e6mia there is more than a mere functional disturbance of the marrow. The marrow appears to be fundamentally and organically affected, and this appears to be the pathological basis of the disease\u2014a point which has already been discussed more fully elsewhere [14]. A parallel may be drawn between the varieties of aplastic an\u00e6mia, such as already exists for ordinary an\u00e6mias. We have, thus, the secondary or benign an\u00e6mias on the one hand; and, on the other, the primary or malignant an\u00e6mias, such as pernicious an\u00e6mia. Correspondingly, we have such benign or secondary aplastic an\u00e6mias as that described in the pigs; and malignant or primary aplastic an\u00e6mias such as those in benzol poisoning, etc. That aplasia should be so marked a feature in iron deficiency, as compared with other secondary an\u00e6mias, is probably due to the persisting nature of the cause.<\/jats:p>","DOI":"10.1177\/003591572802100933","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T03:34:19Z","timestamp":1563507259000},"page":"1581-1592","source":"Crossref","is-referenced-by-count":1,"title":["A Further Contribution to the Subject of Aplastic An\u00e6mia"],"prefix":"10.1177","volume":"21","author":[{"given":"J. P.","family":"McGowan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"bibr-bibr1-003591572802100933","volume-title":"Pernicious An\u00e6mia, Leuk\u00e6mia and Aplastic An\u00e6mia","author":"McGowan J. P.","year":"1926"},{"key":"bibr-bibr2-003591572802100933","first-page":"316","author":"Davies D. T.","year":"1927","journal-title":"Brit. Journ. Exp. Path."},{"key":"bibr-bibr3-003591572802100933","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1007\/BF01716883","author":"Adler E.","year":"1922","journal-title":"Klin. Woch."},{"key":"bibr-bibr4-003591572802100933","first-page":"179","author":"Thannhauser J. S.","year":"1921","journal-title":"Deutsch. Arch. f. klin. Med."},{"key":"bibr-bibr6-003591572802100933","unstructured":"McGowan J. P.\n                      loc. cit.\n                      , chap, ii, 24; and On Rous, Leucotic and Allied Tumours in the Fowl, London, H. K. Lewis, 1928, chap, i, 1."},{"key":"bibr-bibr7-003591572802100933","first-page":"163","author":"Doan Cunningham","year":"1925","journal-title":"Contrib. to Embryology"},{"key":"bibr-bibr9-003591572802100933","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1001\/jama.1926.02680070016005","author":"Minot G. R.","year":"1926","journal-title":"Journ. Amer. Med. Assoc."},{"key":"bibr-bibr11-003591572802100933","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF01993807","author":"Ellermann V.","year":"1920","journal-title":"Virchow's Archiv f. path. Anat. (etc)"},{"key":"bibr-bibr12-003591572802100933","first-page":"15","author":"Helly K.","year":"1910","journal-title":"Beit. z. path. Anat. u. z. allg. Path."},{"key":"bibr-bibr13-003591572802100933","first-page":"179","author":"Peabody","year":"1927","journal-title":"Amer. Journ. Path."}],"container-title":["Proceedings of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003591572802100933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003591572802100933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:13:50Z","timestamp":1777526030000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/003591572802100933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1928,7]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9]]},"published-print":{"date-parts":[[1928,7]]}},"alternative-id":["10.1177\/003591572802100933"],"URL":"https:\/\/doi.org\/10.1177\/003591572802100933","relation":{},"ISSN":["0035-9157"],"issn-type":[{"value":"0035-9157","type":"print"}],"subject":[],"published":{"date-parts":[[1928,7]]}}}