{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:51:57Z","timestamp":1777863117247,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1937,7,1]],"date-time":"1937-07-01T00:00:00Z","timestamp":-1025740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Proceedings of the Royal Society of Medicine"],"published-print":{"date-parts":[[1937,7]]},"abstract":"<jats:p>It is shown in this paper that the infecting organisms in the parodontal sulcus are confined to the surface, but may be forced into the blood and lymph stream by traumatic interference. Local and general disturbances may therefore arise both as a result of the absorption of soluble toxic matter from the pocket into the tissues and also as a result of this traumatic introduction of organisms into the blood-stream. The effect of toxic absorption on the local tissues is destruction of the attachment of the tooth-pyorrh\u0153a. The remote effects of toxic absorption may be a similar destruction of the connective tissue generally-arthritis and fibrositis. The liver and kidney may suffer since they excrete the toxic matter, and other susceptible tissues may also be involved. Traumatic bacter\u00e6mia may produce local bone necrosis or \u201cdry\u201d socket. Acute suppurative lymphangitis produces the \u201cpyorrh\u0153tic abscess\u201d. The remote effect of bacter\u00e6mia may be to produce osteomyelitis (e.g. of the tibia) or to convert a simple endocarditis into the bacterial type. The mechanism of bone absorption and deposition in response to irritation is discussed. Methods of eliminating parodontal infection are referred to and the importance of complete elimination is stressed. It is shown to be not incompatible with the conservation of the teeth.<\/jats:p>","DOI":"10.1177\/003591573703000934","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T02:52:15Z","timestamp":1563504735000},"page":"1149-1165","source":"Crossref","is-referenced-by-count":2,"title":["Local and Remote Sequel\u00e6 of Infection in the Parodontal Sulcus"],"prefix":"10.1177","volume":"30","author":[{"given":"E. Wilfred","family":"Fish","sequence":"first","affiliation":[{"name":"from the John Hampton Hale Research Laboratory, Royal Dental Hospital and School of Dental Surgery, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"bibr-bibr1-003591573703000934","first-page":"531","volume":"58","author":"Fish E. W.","year":"1935","journal-title":"Brit. Bent. J."},{"key":"bibr-bibr2-003591573703000934","first-page":"336","volume":"61","author":"Fish E. W.","year":"1936","journal-title":"Brit. Dent. J."},{"key":"bibr-bibr3-003591573703000934","unstructured":"Gottlieb B., Orban B. \u201cDie Verauderungen der Gewebe bei ubermaziger Beanspruchung der Zahne\u201d, Leipzig, p. 26."},{"key":"bibr-bibr5-003591573703000934","volume-title":"\u201cThe Normal and Pathological Physiology of Bone\u201d","author":"Leriche R.","year":"1928"},{"key":"bibr-bibr6-003591573703000934","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1177\/003591573602901029","volume":"29","author":"MacGregor A.","year":"1936","journal-title":"Proc. Roy. Soc. Med."},{"key":"bibr-bibr7-003591573703000934","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(00)47788-3","author":"Okell C. C.","year":"1935","journal-title":"Lancet"},{"key":"bibr-bibr8-003591573703000934","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1177\/003591573602901206","volume":"29","author":"Round H.","year":"1936","journal-title":"Proc. Roy. Soc. Med."},{"key":"bibr-bibr9-003591573703000934","first-page":"473","volume":"58","author":"Stewart-Ross W.","year":"1935","journal-title":"Brit. Dent. J."},{"key":"bibr-bibr10-003591573703000934","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/bmj.1.3153.804","author":"Willcox W. H.","year":"1921","journal-title":"Brit. M. J."}],"container-title":["Proceedings of the Royal Society of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003591573703000934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/003591573703000934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:20:58Z","timestamp":1777526458000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/003591573703000934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1937,7]]},"references-count":9,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9]]},"published-print":{"date-parts":[[1937,7]]}},"alternative-id":["10.1177\/003591573703000934"],"URL":"https:\/\/doi.org\/10.1177\/003591573703000934","relation":{},"ISSN":["0035-9157"],"issn-type":[{"value":"0035-9157","type":"print"}],"subject":[],"published":{"date-parts":[[1937,7]]}}}