{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:37Z","timestamp":1792108837622,"version":"4.4.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Nature Science Foundation of China","award":["81771899"],"award-info":[{"award-number":["81771899"]}]},{"name":"Jiangsu Province Hospital of peak academic personnel training project","award":["y2018rc04"],"award-info":[{"award-number":["y2018rc04"]}]},{"name":"the Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["SJCX20_0514"],"award-info":[{"award-number":["SJCX20_0514"]}]},{"name":"Key Project of Chinese Medicine Technology Development Plan of Jiangsu Province","award":["ZD201907"],"award-info":[{"award-number":["ZD201907"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>To explore the clinical features, imaging findings, and pathological manifestations of ovarian Sertoli-Leydig cell tumors (SLCTs). The clinical and pathological manifestations, tumor location, size, morphology, vascularity, computed tomography (CT) density, magnetic resonance imaging (MRI) signal intensity, and contrast enhancement patterns in five cases with SLCTs were retrospectively reviewed. SLCTs most commonly occurred in young women. Virilization was observed in three cases (60%). All five tumors were unilateral and oval or round, with a clear boundary. The solid part of the tumor was isoattenuated on the conventional CT scan, and showed isoattenuation or slight hypoattenuation relative to adjacent myometrium on T1 weighted imaging (T1WI) and T2 weighted imaging (T2WI). On contrast-enhanced images, three tumors showed marked enhancement. DICER1 hotspot mutations were commonly seen in SLCTs. A highly vascularized mass with low signal intensity (SI) of the solid part on T2WI and androgen overproduction symptoms may suggest an SLCT.<\/jats:p>","DOI":"10.1177\/00368504211009668","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T14:35:33Z","timestamp":1618324533000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Imaging, clinical, and pathologic findings of Sertoli-leydig cell tumors"],"prefix":"10.1177","volume":"104","author":[{"given":"Jingya","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-4302","authenticated-orcid":false,"given":"Zhongqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"bibr1-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-018-0562-3"},{"key":"bibr2-00368504211009668","first-page":"858501","volume":"2013","author":"Abu-Zaid A","year":"2013","journal-title":"Case Rep Obstet Gynecol"},{"key":"bibr3-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.01928.x"},{"key":"bibr4-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.07.114"},{"key":"bibr5-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198508000-00001"},{"key":"bibr6-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1186\/1757-2215-6-73"},{"key":"bibr7-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2008.05.006"},{"key":"bibr8-00368504211009668","first-page":"35","volume":"6","author":"Rathi M","year":"2015","journal-title":"J Midlife Health"},{"key":"bibr9-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.03.024"},{"key":"bibr10-00368504211009668","volume":"9","author":"Sharma S","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"bibr11-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1080\/15476278.2016.1145318"},{"key":"bibr12-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1111\/his.14123"},{"key":"bibr13-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001232"},{"key":"bibr14-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.09.034"},{"key":"bibr15-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000895"},{"key":"bibr16-00368504211009668","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10050143"},{"key":"bibr17-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-3089"},{"key":"bibr18-00368504211009668","volume-title":"GeneReviews","author":"Schultz KAP"},{"key":"bibr19-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e31823d7fcd"},{"key":"bibr20-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000083"},{"key":"bibr21-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200209000-00016"},{"key":"bibr22-00368504211009668","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2016.016261"},{"key":"bibr23-00368504211009668","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2014.57.5.405"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504211009668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504211009668","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504211009668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:02:46Z","timestamp":1777633366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504211009668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1177\/00368504211009668"],"URL":"https:\/\/doi.org\/10.1177\/00368504211009668","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"article-number":"00368504211009668"}}