{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:48:17Z","timestamp":1791204497369,"version":"4.2.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Cyanide is an environmental neurotoxin which has been reported to arrest the normal functioning of the brain. This study investigated the protective properties of methanol and flavonoid-rich extracts of the leaves of Spondias mombin on redox status, cholinergic dysfunction and electrolyte disturbance in cyanide-induced neurotoxicity in rats. Male Wistar rats were orally pre-treated with Spondias mombin methanol leaf extract (SMC) (50, 100 and 150\u2009mg\/kg), flavonoid-rich extract (SMF) (25, 50 and 75\u2009mg\/kg) or quercetin (20\u2009mg\/kg), followed by intraperitoneal administration of 2\u2009mg\/kg potassium cyanide. Cyanide intoxication caused brain damage in rats as echoed in the deleterious alterations to activities\/levels of endogenous antioxidants and biomarkers\/enzymes linked with electrolyte imbalance and neurotoxicity. Pre-treatment with SMC and SMF significantly attenuated these KCN-induced imbalances ( p\u2009&lt;\u20090.05). The results suggested that the protection conferred by SMC and SMF probably involves attenuation of oxidative stress and regulation of ionic homeostasis. SMF displayed a better apparent ameliorative activity than SMC and 75\u2009mg\/kg SMF offered the best protection suggesting that flavonoids probably contributed to the protective effect of Spondias mombin leaf.<\/jats:p>","DOI":"10.1177\/00368504211011866","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T07:55:29Z","timestamp":1619682929000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Protective properties of\n                    <i>Spondias mombin<\/i>\n                    Linn leaves on redox status, cholinergic dysfunction and electrolyte disturbance in cyanide-intoxicated rats"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-1235","authenticated-orcid":false,"given":"Afolabi Clement","family":"Akinmoladun","sequence":"first","affiliation":[{"name":"Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, Akure, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adesola Adebusayo","family":"Adelabu","sequence":"additional","affiliation":[{"name":"Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, Akure, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Olabayode","family":"Saliu","sequence":"additional","affiliation":[{"name":"Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, Akure, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanuoluwapo Ruth","family":"Adetuyi","sequence":"additional","affiliation":[{"name":"Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, Akure, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Tolulope","family":"Olaleye","sequence":"additional","affiliation":[{"name":"Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, Akure, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"bibr1-00368504211011866","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-015-5286-9"},{"key":"bibr2-00368504211011866","doi-asserted-by":"crossref","unstructured":"Brenner M, Mahon-Brenner S, Patterson SE, et al. 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