{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:31:55Z","timestamp":1777901515212,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>In several parts of the world, Boswellia sacra Fluck. is one of the most commonly used herbs for the treatment of arthritis. Its usage should be validated in light of recent findings of haematotoxicity. This study was aimed to determine the effect of chronic administration of standardized methanolic extract of frankincense on blood cell count in experimental animals. Using high-performance liquid chromatography, the active constituents of B. sacra extract; boswellic acids were analyzed. The effect of three different doses of the extract (250, 500, and 1000\u2009mg\/kg) on different blood cells and associated parameters was investigated. The behavior, food, and water consumption of the rats were recorded. Boswellic acids were present in varying amounts with \u03b1-boswellic acid and \u03b2-boswellic acid present in more amounts compared to other boswellic acids in the extract. All three doses tested had no effect on the animals\u2019 behavior, food consumption, or weight gain. The administration of a low (500\u2009mg\/kg) and high (1000\u2009mg\/kg) dose of the extract resulted in a non-dose dependent reduction in MCH ( p\u2009&lt;\u20090.01 and p\u2009&lt;\u20090.05, respectively), but no other blood parameters were significantly affected. The B. sacra extract produces hypochromic normocytic anemia in rats at higher doses of 500 and 1000\u2009mg\/kg and this effect was not dose-dependent.<\/jats:p>","DOI":"10.1177\/00368504211015102","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T02:49:03Z","timestamp":1620528543000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Haematotoxic effects of methanolic extract of\n                    <i>Boswellia sacra<\/i>\n                    oleo gum resin (frankinccense) in rats"],"prefix":"10.1177","volume":"104","author":[{"given":"AbdulRahman A I","family":"Alyahya","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Asad","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1533-9667","authenticated-orcid":false,"given":"Syed Mohammed Basheeruddin","family":"Asdaq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahya","family":"Mohzari","sequence":"additional","affiliation":[{"name":"Clinical pharmacy department, King Saud Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Alrashed","sequence":"additional","affiliation":[{"name":"Pharmaceutical services administration, Inpatient Department, main hospital, KFMC, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdan Najib","family":"Alajami","sequence":"additional","affiliation":[{"name":"Pharmaceutical Services Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awad Othman","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Pharmaceutical Services Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Ali","family":"Al Mushtawi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Services Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AssilNajib","family":"Alajmi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Services Administration, Health Oasis Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan Nageeb","family":"Alajmi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Services Administration, Health Oasis Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"issue":"1","key":"bibr1-00368504211015102","first-page":"40","volume":"7","author":"Pendota SC","year":"2010","journal-title":"African J Tradit Complement Altern Med"},{"key":"bibr2-00368504211015102","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1200553"},{"key":"bibr3-00368504211015102","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/140509"},{"key":"bibr4-00368504211015102","doi-asserted-by":"publisher","DOI":"10.1111\/lam.12683"},{"key":"bibr5-00368504211015102","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-3637-4"},{"key":"bibr6-00368504211015102","doi-asserted-by":"publisher","DOI":"10.1159\/000468988"},{"key":"bibr7-00368504211015102","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1028553"},{"key":"bibr8-00368504211015102","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2019.05.010"},{"key":"bibr9-00368504211015102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112890"},{"issue":"11","key":"bibr10-00368504211015102","first-page":"1374","volume":"23","author":"Mahdian D","year":"2020","journal-title":"Iran J Basic Med Sci"},{"issue":"6","key":"bibr11-00368504211015102","first-page":"509","volume":"43","author":"Pandey RS","year":"2005","journal-title":"Indian J Exp Biol"},{"issue":"3","key":"bibr12-00368504211015102","first-page":"115","volume":"32","author":"Matsumoto K","year":"1983","journal-title":"Jikken Dobutsu"},{"key":"bibr13-00368504211015102","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjbas.2013.09.004"},{"key":"bibr14-00368504211015102","unstructured":"Victor Hoffbrand A, Steensma DP. Hoffbrand\u2019s essential haematology. 8th ed. Hoboken, New Jersey, USA: Wiley. https:\/\/www.wiley.com\/en-us\/Hoffbrand%27s+Essential+Haematology%2C+8th+Edition-p-9781119495901 (accessed 16 November 2020)."}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504211015102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504211015102","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504211015102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:03:20Z","timestamp":1777633400000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504211015102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1177\/00368504211015102"],"URL":"https:\/\/doi.org\/10.1177\/00368504211015102","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"article-number":"00368504211015102"}}