{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:29:27Z","timestamp":1793316567391,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2_suppl","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls ( p\u2009&lt;\u20090.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity ( r\u2009=\u20090.793, p\u2009&lt;\u20090001; r\u2009=\u20090.521, p\u2009&lt;\u20090.001; and r\u2009=\u20090,533, p\u2009&lt;\u20090.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.<\/jats:p>","DOI":"10.1177\/00368504211026119","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T03:58:30Z","timestamp":1625025510000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2\u2013infected patients"],"prefix":"10.1177","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-412X","authenticated-orcid":false,"given":"Abdurrahim","family":"Kocyigit","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Bezmialem Vakif University, Istanbul, 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