{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:21:39Z","timestamp":1789507299507,"version":"build-2803163510"},"reference-count":64,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We sought to screen for clinical and laboratory features of hemophagocytic lymphohistiocytosis among pediatric patients with severe sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective study that analyzed the clinical and laboratory data of 70 pediatric patients who died of severe sepsis. Medical records were revised for the presence of fever, splenomegaly, pancytopenia, hyperferritinemia, hypertriglyceridemia, and hypofibrinogenemia. Soluble CD25 was measured in stored samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients\u2019 ages ranged between 0.5 and 11 years with median (interquartile range) 2 (1\u20135). All patients had fever (\u226538.5\u2005\u00b0C) and pancytopenia, 58 (82.9%) hepatosplenomegaly, 36 (51.4%) lymphadenopathy, 37 (52.9%) had ferritin &gt;500\u2005ng\/ml, 20 (28.6%) had fibrinogen &lt;1.5\u2005mg\/ml, 14 (20%) had fasting triglycerides &gt;264\u2005mg\/dl while 5 (7.1%) had soluble CD25 &gt;2400\u2005U\/ml. Twenty-five (35.7%) patients fulfilled at least 5\/6 of the hemophagocytic lymphohistiocytosis-2004 diagnostic criteria. Multivariate backward binary logistic regression analysis revealed lymphadenopathy as an independent predictor for hemophagocytic lymphohistiocytosis criteria fulfilment with odds ratio of 23.9. Fibrinogen had the best performance in discriminating hemophagocytic lymphohistiocytosis fulfilling from non-fulfilling groups (cut-off value: &lt;1.8\u2005mg\/ml), followed by ferritin\/erythrocyte sedimentation rate ratio (cut-off value: &gt;17).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a significant clinical and laboratory overlap between hemophagocytic lymphohistiocytosis and severe sepsis, making the syndromes difficult to distinguish. The use of current hemophagocytic lymphohistiocytosis-2004 diagnostic criteria should be applied cautiously in those patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504211044042","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T10:55:41Z","timestamp":1631616941000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Screening of hemophagocytic lymphohistiocytosis in children with severe sepsis in pediatric intensive care"],"prefix":"10.1177","volume":"104","author":[{"given":"Zeinab A","family":"El-Sayed","sequence":"first","affiliation":[{"name":"Pediatric Allergy and Immunology Unit, Children\u2019s Hospital, Ain Shams University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha H","family":"El-Owaidy","sequence":"additional","affiliation":[{"name":"Pediatric Allergy and Immunology Unit, Children\u2019s Hospital, Ain Shams University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A","family":"Khamis","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit, Children\u2019s Hospital, Ain Shams University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-9734","authenticated-orcid":false,"given":"Ahmed R","family":"Rezk","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Children\u2019s Hospital, Ain Shams University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"bibr1-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21236"},{"key":"bibr2-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-014-0274-1"},{"key":"bibr3-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"bibr4-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001222"},{"key":"bibr5-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0619"},{"key":"bibr6-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1369-3"},{"key":"bibr7-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181a1ae08"},{"key":"bibr8-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-356261"},{"key":"bibr9-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-017-0377-7"},{"key":"bibr10-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24188"},{"key":"bibr11-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-697151"},{"key":"bibr12-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-120810"},{"key":"bibr13-00368504211044042","first-page":"223","volume":"24","author":"Gosh JB","year":"2009","journal-title":"Oman Med J"},{"key":"bibr14-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000149131.72248.E6"},{"key":"bibr15-00368504211044042","first-page":"2863","author":"Kliegman RM","year":"2015","journal-title":"Neurol Part P"},{"key":"bibr16-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1309\/EK3C7CTDKNVPXVTN"},{"key":"bibr17-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"bibr18-00368504211044042","doi-asserted-by":"publisher","DOI":"10.2478\/v10117-011-0021-1"},{"key":"bibr19-00368504211044042","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-011-0055-4"},{"key":"bibr20-00368504211044042","unstructured":"WHO. 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