{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:50:01Z","timestamp":1778827801026,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The authors are grateful to the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University, through the Research Funding Program (RGP-1442 - 6), for funding this work."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>This study tested the protective effect of Rumex nervous (R. nervosus) methanol extract against streptozotocin (STZ)-mediated type 1 diabetes mellitus (T1DM)-induced nephropathy in rats and examined if this protection involves activating the nuclear factor erythroid 2 related factor-2 (Nrf2). Rats were divided into control, R. nervous (300\u2005mg), STZ (T1DM), STZ\u2009+\u2009 R. nervosus (100, 200, or 300\u2005mg\/kg), and STZ\u2009+\u2009 R. nervosus (300\u2005mg\/kg)\u2009+\u2009brusatol (an Nrf2 inhibitor). With no effect on fasting glucose and insulin levels, R. nervosus methanol extract preserved kidney histological structure and alterations kidney function markers (e.g. albumin, creatinine, and urine volume) in the STZ-diabetic rats. R. nervosus also reduced levels of reactive oxygen species (ROS), malondialdehyde (MDA), tumor necrosis factor-\u03b1 (TNF-\u03b1), and interleukine-6 (IL-6), nuclear levels of the nuclear factor kappa beta (NF-\u03baB), and mRNA of caspase-3 and Bax in the kidneys of these diabetic rats. Concomitantly, it stimulated renal mRNA levels of Bcl2 and Nrf2, cytoplasmic and nuclear levels of Nrf2, and levels of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). All these effects were dose-dependent, with the maximum effect seen with the 300\u2005mg\/kg dose, all prevented by brusatol. Also, these effects occurred without any alteration in the transcription of the Kelch-like ECH-associated protein 1 (keap-1). Similar effects on levels of GSH, SOD, CAT, and NF-\u03baB, as well as expression of Nrf2, were also observed in the kidney of control\u2009+\u2009 R. nervous-treated rats. In conclusion, R. nervosus prevents diabetic nephropathy in rats by upregulating and activating Nrf2.<\/jats:p>","DOI":"10.1177\/00368504221102751","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T01:43:42Z","timestamp":1653615822000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Rumex nervosus<\/i>\n                    could alleviate streptozotocin-induced diabetic nephropathy in rats by activating Nrf2 signaling"],"prefix":"10.1177","volume":"105","author":[{"given":"Lujain A","family":"AlMousa","sequence":"first","affiliation":[{"name":"Nutrition and Food Science, Department of Physical Sport Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-5725","authenticated-orcid":false,"given":"Nora 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