{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:20:42Z","timestamp":1780759242651,"version":"3.54.1"},"reference-count":13,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the General Research Project of Education Department of Zhejiang Province","award":["Y202045121"],"award-info":[{"award-number":["Y202045121"]}]},{"name":"the Traditional Chinese Medical Science and Technology Project of Zhejiang Province","award":["2021ZB122"],"award-info":[{"award-number":["2021ZB122"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Eltrombopag, a kind of thrombopoietin (TPO) receptor agonist, plays the role on the megakaryocyte to activate the platelet production and rapidly increase the number of circulating platelets in patients with primary immune thrombocytopenia (ITP). Eltrombopag provides an opportunity for rapid tapering and\/or cessation of corticosteroid therapy. However, it is not clear about the platelet response to Eltrombopag in ITP associated with Sj\u00f6gren's Syndrome(SS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective research was conducted on the clinical course of three patients, each with ITP secondary to SS, and initially received therapy of corticosteroids or other immunomodulatory. They took this drug for bleeding diseases. Referring to the description, Eltrombopag was prescribed and adjusted with an initial dose of 25\u2005mg daily, then weekly, then monthly according to the monitoring of platelet counts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All patients maintained a satisfactory level of platelet counts (&gt;100,000\/mm\n                      <jats:sup>3<\/jats:sup>\n                      for &gt;2 years) following corticosteroid withdrawal. Meanwhile, Eltrombopag was well-tolerated, and there were no adverse effects, such as thrombotic events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Eltrombopag is effective and safe for patients with ITP associated with SS during corticosteroid withdrawal. Thus it may be a crucial therapeutic strategy for reducing corticosteroid-related side effects in SS patients with ITP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504221102786","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T02:25:10Z","timestamp":1653272710000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Eltrombopag improves refractory thrombocytopenia in patients with Sj\u00f6gren's syndrome"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3683-6056","authenticated-orcid":false,"given":"Liping","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3496-2999","authenticated-orcid":false,"given":"Na","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoding","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,22]]},"reference":[{"key":"bibr1-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1702514"},{"key":"bibr2-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1810479"},{"key":"bibr3-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302984"},{"key":"bibr4-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93646-2"},{"key":"bibr5-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"bibr6-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.45"},{"key":"bibr7-00368504221102786","doi-asserted-by":"publisher","DOI":"10.5045\/br.2015.50.1.19"},{"key":"bibr8-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318770023"},{"key":"bibr9-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13446"},{"key":"bibr10-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84493-2"},{"key":"bibr11-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210571"},{"key":"bibr12-00368504221102786","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00066"},{"key":"bibr13-00368504221102786","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003599"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504221102786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504221102786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504221102786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:08:12Z","timestamp":1777633692000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504221102786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/00368504221102786"],"URL":"https:\/\/doi.org\/10.1177\/00368504221102786","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"article-number":"00368504221102786"}}