{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:35:28Z","timestamp":1777901728619,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Seoul National University Hospital research fund","award":["04-2016-0350"],"award-info":[{"award-number":["04-2016-0350"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The level of vitamin D in follicular fluid (FF) according to the ovarian reserve has never been investigated, and the effect of FF vitamin D on the outcome of assisted reproductive technology (ART) remains controversial. The aim of this study is to evaluate the association between FF vitamin D levels and baseline anti-M\u00fcllerian hormone (AMH) \/ ART outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-seven patients who underwent controlled ovarian stimulation at the fertility clinic of an academic tertiary care center were enrolled for a prospective observational study. FF was collected from the first aspirated leading follicle of each ovary and assayed by an enzyme-linked immunosorbent assay. Multivariable linear regression analysis was used to assess the association between baseline AMH and FF vitamin D levels with adjustment for basal FSH and serum vitamin D levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both the AMH and serum vitamin D were significant predictors for FF vitamin D. The estimated marginal mean of FF vitamin D level was higher in women with decreased ovarian reserve (DOR) than those with normal ovarian reserve (24.1\u2009\u00b1\u20092.1 vs. 18.8\u2009\u00b1\u20091.4\u2005ng\/ml, p\u2009=\u20090.048). However, FF vitamin D did not demonstrate any significant associations with cycle outcomes, including fertilization rate and the number and proportion of good embryos at day three.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed significantly higher FF vitamin D levels in women with DOR. However, FF vitamin D did not demonstrate any significant associations with the outcome of ART. A larger prospective study is needed to investigate the effect of FF vitamin D on the clinical pregnancy rate and live birth rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504221103782","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T01:44:05Z","timestamp":1653615845000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The level of vitamin D in follicular fluid and ovarian reserve in an in vitro fertilization program: A pilot study"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-3188","authenticated-orcid":false,"given":"Ji Yeon","family":"Han","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-1323","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-6368","authenticated-orcid":false,"given":"Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-854X","authenticated-orcid":false,"given":"Seung-Yup","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea"},{"name":"Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"bibr1-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"bibr2-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0910059"},{"key":"bibr3-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2005.06.002"},{"key":"bibr4-00368504221103782","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(89)79170-0"},{"key":"bibr5-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.4.7403"},{"key":"bibr6-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.04.046"},{"key":"bibr7-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0984"},{"key":"bibr8-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00126.x"},{"key":"bibr9-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex326"},{"key":"bibr10-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.11.015"},{"key":"bibr11-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-8-91"},{"key":"bibr12-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1179-4"},{"key":"bibr13-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2959-9"},{"key":"bibr14-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.05.019"},{"key":"bibr15-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.025"},{"key":"bibr16-00368504221103782","volume-title":"Atlas of the human oocyte and early conceptus","author":"Veeck LL","year":"1991"},{"key":"bibr17-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-016-0143-3"},{"key":"bibr18-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.plabm.2015.04.001"},{"key":"bibr19-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.12.003"},{"key":"bibr20-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.09.134"},{"key":"bibr21-00368504221103782","unstructured":"Study of dehydroepiandrosterone treatment for poor responders in in vitro fertilization patients, https:\/\/clinicaltrials.gov\/ct2\/history\/NCT01535872?V_8=View (2012, updated 07 August 2018; cited 10 August 2021)."},{"key":"bibr22-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2015.06.015"},{"key":"bibr23-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp036"},{"key":"bibr24-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-018-0435-7"},{"key":"bibr25-00368504221103782","first-page":"208","volume":"32","author":"Drakopoulos P","year":"2016","journal-title":"Hum Reprod"},{"key":"bibr26-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.05.009"},{"key":"bibr27-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.05.005"},{"key":"bibr28-00368504221103782","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070719"},{"key":"bibr29-00368504221103782","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051053"},{"key":"bibr30-00368504221103782","first-page":"105","volume":"11","author":"Aghadavod E","year":"2017","journal-title":"Int J Fertil Steril"},{"key":"bibr31-00368504221103782","first-page":"132","volume":"20","author":"Masjedi F","year":"2019","journal-title":"J Reprod Infertil"},{"key":"bibr32-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.12.010"},{"key":"bibr33-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1555"},{"key":"bibr34-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-021-06174-9"},{"key":"bibr35-00368504221103782","first-page":"280","volume":"15","author":"Neysanian GH","year":"2021","journal-title":"Int J Fertil Steril"},{"key":"bibr36-00368504221103782","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.609524"},{"key":"bibr37-00368504221103782","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3185"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504221103782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504221103782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504221103782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:08:16Z","timestamp":1777633696000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504221103782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/00368504221103782"],"URL":"https:\/\/doi.org\/10.1177\/00368504221103782","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"article-number":"00368504221103782"}}