{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:50:08Z","timestamp":1790193008180,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Direct-acting antiviral (DAA) regimens and telemedicine services are both options for treating hepatitis C virus (HCV) within the prison setting. We aimed to compare factors associated with HCV treatment success over the past decade in Israeli prisons, specifically the influence of DAAs and telemedicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the medical records of inmates with HCV infection in Israeli prisons from 2010 through 2020. Demographic, clinical, and laboratory data were recorded, including treatment regimens and success rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 273 inmates were treated; mean age 45\u2009\u00b1\u20099.36 years; 98.2% males; 63.9% with a history of drug abuse. Advanced fibrosis was documented in 42.9%. The most common genotypes were 1 (46%) followed by 3 (40.7%). Interferon-based regimens were given to 68 inmates between 2010 and 2017. DAA agents were introduced in 2016, with pan-genotype regimens being exclusively used since 2019. Telemedicine services were used in 140 patients (51.3%), starting in February 2019. The sustained viral response (SVR) rate with interferon-based therapy was 78.8% and 98.8% with DAA treatment, giving an overall SVR of 93.2%. This difference between regimens proved to be the only statistically significant predictor of treatment success. The number of prisoners being treated with DAAs increased exponentially after telemedicine was introduced. Comparable SVR rates were achieved with either in-person or telemedicine consultation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Screening of this high-risk population and using telemedicine for treatment may be an effective strategy for the elimination of HCV from the prison population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504221105173","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:16:28Z","timestamp":1655684188000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of direct-acting antiviral regimens and telemedicine on the treatment of inmates with hepatitis C virus infection in Israeli prisons"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6003-9220","authenticated-orcid":false,"given":"Vered","family":"Richter","sequence":"first","affiliation":[{"name":"The Gonczarowski Family Institute of Gastroenterology and Liver Disease, Shamir (Assaf Harofeh) Medical Center, Zerifin, 70300, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liav","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Chief Medical Officer Office, Israel Prison Service, POB 81, Ramla, 72100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Gonczarowski Family Institute of Gastroenterology and Liver Disease, Shamir (Assaf Harofeh) Medical Center, Zerifin, 70300, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-8779","authenticated-orcid":false,"given":"Anton","family":"Bermont","sequence":"additional","affiliation":[{"name":"The Gonczarowski Family Institute of Gastroenterology and Liver Disease, Shamir (Assaf Harofeh) Medical Center, Zerifin, 70300, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-5061","authenticated-orcid":false,"given":"Dana","family":"Zelnik Yovel","sequence":"additional","affiliation":[{"name":"The Gonczarowski Family Institute of Gastroenterology and Liver Disease, Shamir (Assaf Harofeh) Medical Center, Zerifin, 70300, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Madar","sequence":"additional","affiliation":[{"name":"Chief Medical Officer Office, Israel Prison Service, POB 81, Ramla, 72100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Rabinovitch","sequence":"additional","affiliation":[{"name":"Chief Medical Officer Office, Israel Prison Service, POB 81, Ramla, 72100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Shirin","sequence":"additional","affiliation":[{"name":"The Gonczarowski Family Institute of Gastroenterology and Liver Disease, Shamir (Assaf Harofeh) Medical Center, Zerifin, 70300, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-8491","authenticated-orcid":false,"given":"Efrat","family":"Broide","sequence":"additional","affiliation":[{"name":"The Gonczarowski Family Institute of Gastroenterology and Liver Disease, Shamir (Assaf Harofeh) Medical Center, Zerifin, 70300, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"The Jecheskiel Sigi Gonczarowski Pediatric Gastroenterology Unit, Shamir (Assaf Harofeh) Medical Center, Zerifin, 70300, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,19]]},"reference":[{"key":"bibr1-00368504221105173","unstructured":"World Health Organization: Hepatitis C. Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-c. Accessed 10 December 2020."},{"key":"bibr2-00368504221105173","doi-asserted-by":"publisher","DOI":"10.21037\/TGH.2018.02.03"},{"key":"bibr3-00368504221105173","first-page":"1","author":"Stevenson WJ","year":"2016","journal-title":"World Prison Br - Inst Crim Policy Res"},{"key":"bibr4-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2019.11.001"},{"key":"bibr5-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-020-00431-x"},{"key":"bibr6-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4581-3"},{"key":"bibr7-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa301"},{"key":"bibr8-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2014.07.018"},{"key":"bibr9-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1086\/430913"},{"key":"bibr10-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1177\/0033354920988610"},{"key":"bibr11-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy585"},{"key":"bibr12-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26387"},{"key":"bibr13-00368504221105173","unstructured":"AASLD-IDSA. HCV Testing and Treatment in Correctional Settings. Recommendations for testing, managing, and treating hepatitis C. Available at: https:\/\/www.hcvguidelines.org\/unique-populations\/correctional. Accessed 11 December 2020."},{"key":"bibr14-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2016.0296"},{"key":"bibr15-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx142"},{"key":"bibr16-00368504221105173","first-page":"550","volume":"111","author":"Jim\u00e9nez-Gal\u00e1n G","year":"2019","journal-title":"Rev Esp Enfermedades Dig"},{"key":"bibr17-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1177\/1357633X18795361"},{"key":"bibr18-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"bibr19-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.008"},{"key":"bibr20-00368504221105173","unstructured":"FI-BROCHURES: The FibroTest ActiTest HCV FIBROSURE investigator's brochure. Available from: URL: http:\/\/library.biopredictive.com"},{"key":"bibr21-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5926-3-8"},{"key":"bibr22-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12998"},{"key":"bibr23-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31818dd94c"},{"key":"bibr24-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1086\/591707"},{"key":"bibr25-00368504221105173","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2004.056150"},{"key":"bibr26-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0157-x"},{"key":"bibr27-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14745"},{"key":"bibr28-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2018.06.017"},{"key":"bibr29-00368504221105173","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i35.8050"},{"key":"bibr30-00368504221105173","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3117"},{"key":"bibr31-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.06.033"},{"key":"bibr32-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.07.042"},{"key":"bibr33-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1177\/00333549071220S214"},{"key":"bibr34-00368504221105173","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2015.159000"},{"key":"bibr35-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13017"},{"key":"bibr36-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2020.103031"},{"key":"bibr37-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.3.286"},{"key":"bibr38-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1177\/1078345818762591"},{"key":"bibr39-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13392"},{"key":"bibr40-00368504221105173","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-374"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504221105173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504221105173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504221105173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:08:19Z","timestamp":1777633699000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504221105173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/00368504221105173"],"URL":"https:\/\/doi.org\/10.1177\/00368504221105173","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"article-number":"00368504221105173"}}