{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:35:57Z","timestamp":1777901757947,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NRCT Thailand","award":["NRCT 820\/2563"],"award-info":[{"award-number":["NRCT 820\/2563"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Atractylodes lancea, commonly known as Kod-Kamao in Thai, a traditional medicinal herb, is being developed for clinical use in cholangiocarcinoma. \u03b2-eudesmol and atractylodin are the main active components of this herb which possess most of the pharmacological properties. However, the lack of adequate toxicity data would be a significant hindrance to their further development. The present study investigated the toxic effects of selected concentrations of \u03b2-eudesmol and atractylodin in the heart, liver, and endocrine systems of zebrafish embryos. Study endpoints included changes in the expression of genes related to Na\/K-ATPase activity in the heart, fatty acid-binding protein 10a and cytochrome P450 family 1 subfamily A member 1 in the liver, and cortisol levels in the endocrine system. Both compounds produced inhibitory effects on the Na\/K-ATPase gene expressions in the heart. Both also triggered the biomarkers of liver toxicity. While \u03b2-eudesmol did not alter the expression of the cytochrome P450 family 1 subfamily A member 1 gene, atractylodin at high concentrations upregulated the gene, suggesting its potential enzyme-inducing activity in this gene. \u03b2-eudesmol, but not atractylodin, showed some stress-reducing properties with suppression of cortisol production.<\/jats:p>","DOI":"10.1177\/00368504221137458","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T01:29:25Z","timestamp":1670376565000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of \u03b2-eudesmol and atractylodin on target genes and hormone related to cardiotoxicity, hepatotoxicity, and endocrine disruption in developing zebrafish embryos"],"prefix":"10.1177","volume":"105","author":[{"given":"Gyem","family":"Tshering","sequence":"first","affiliation":[{"name":"Graduate Studies, Chulabhorn International College of Medicine, Thammasat University, Klong Luang, Pathumthani, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-2146","authenticated-orcid":false,"given":"Wittaya","family":"Pimtong","sequence":"additional","affiliation":[{"name":"Nano Environmental and Health Safety Research Team, National Nanotechnology Center, National Science and Technology Development Agency, Klong Luang, Pathumthani, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tullayakorn","family":"Plengsuriyakarn","sequence":"additional","affiliation":[{"name":"Graduate Studies, Chulabhorn International College of Medicine, Thammasat University, Klong Luang, Pathumthani, Thailand"},{"name":"Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Klong Luang, Pathumthani, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6389-0897","authenticated-orcid":false,"given":"Kesara","family":"Na-Bangchang","sequence":"additional","affiliation":[{"name":"Graduate Studies, Chulabhorn International College of Medicine, Thammasat University, Klong Luang, Pathumthani, Thailand"},{"name":"Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Klong Luang, Pathumthani, Thailand"},{"name":"Drug Discovery and Development Center, Thammasat University, Klong Luang, Pathumthani, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"bibr1-00368504221137458","unstructured":"Ouyang Z, Yang L, Su SL, et al. 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