{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:53:58Z","timestamp":1792601638339,"version":"4.5.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000152","name":"Division of Molecular and Cellular Biosciences","doi-asserted-by":"publisher","award":["1943514"],"award-info":[{"award-number":["1943514"]}],"id":[{"id":"10.13039\/100000152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS117686"],"award-info":[{"award-number":["NS117686"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Proton concentration can change within the cleft during synaptic activity due to vesicular release and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    extrusion from cellular compartments. These changes within the synaptic cleft can impact neural activity by proton-dependent modulation of ion channel function. The pH transient differs in magnitude and direction between synapses, requiring different synapse types to be measured to generate a complete understanding of this mechanism and its impacts on physiology. With a focus on the mouse neuromuscular junction (NMJ), the recently published \u201cPostsynaptic Calcium Extrusion at the Mouse Neuromuscular Junction Alkalinizes the Synaptic Cleft\u201d measured synaptic cleft pH at a cholinergic synapse and found a biphasic pH transient. The study demonstrated that the changes in proton concentration found were due to postsynaptic signaling when measuring pH at the muscle membrane, despite the expectation of a presynaptic contribution. This result suggests a diffusional barrier within the NMJ isolates pH transients to presynaptic versus postsynaptic compartments. Generating a Donnan equilibrium that impacts protons, evidence suggests the basal lamina may be a key regulator of pH at the NMJ. Exploring synaptic pH, proton regulating factors, and downstream pH transient effects at presynaptic versus postsynaptic membranes may lead to new insight for a variety of diseases.\n                  <\/jats:p>","DOI":"10.1177\/00368504231225066","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T01:04:40Z","timestamp":1704848680000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Basal lamina: A novel pH regulator at the neuromuscular junction"],"prefix":"10.1177","volume":"107","author":[{"given":"Ryan","family":"Durbin","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7905-4789","authenticated-orcid":false,"given":"Robert","family":"Renden","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno, School of Medicine, Reno, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"bibr1-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2003"},{"key":"bibr2-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00535-9"},{"key":"bibr3-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00948.2009"},{"key":"bibr4-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1774-19.2020"},{"key":"bibr5-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0815-23.2023"},{"key":"bibr6-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.11.035"},{"key":"bibr7-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77154-3"},{"key":"bibr8-00368504231225066","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081235"},{"key":"bibr9-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.229153"},{"key":"bibr10-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000020630.74955.19"},{"key":"bibr11-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.62.237"},{"key":"bibr12-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2807-05.2006"},{"key":"bibr13-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.04.039"},{"key":"bibr14-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2023.09.014"},{"key":"bibr15-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308421110"},{"key":"bibr16-00368504231225066","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.01.026"},{"key":"bibr17-00368504231225066","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168358"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504231225066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504231225066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504231225066","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504231225066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:11:26Z","timestamp":1777633886000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504231225066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/00368504231225066"],"URL":"https:\/\/doi.org\/10.1177\/00368504231225066","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"00368504231225066"}}