{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:37:46Z","timestamp":1777901866762,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Background\/Aim: The ideal treatment of tooth avulsion is replantation. However, replanting teeth may lead to root resorption. Fibroblast growth factor-2 (FGF-2) is a cytokine that plays an important role in wound repair and tissue regeneration. Recently, FGF-2 has been studied a potential regenerative agent to prevent root resorption and ankylosis. The aim of this review is to analyze and summarize the currently available literature focusing on using FGF-2 based regenerative modalities to improve the outcomes of tooth replantation. Materials and Methods: An electronic search was conducted via PubMed\/Medline, Google Scholar and ISI Web of Knowledge, using the Medical Subject Headings (MeSH) terms \u201cBasic fibroblast growth factor,\u201d \u201cFibroblast growth factor-2,\u201d \u201ctooth replantation,\u201d and \u201creplantation\u201d for studies published between January 2001 and June 2021. Data was extracted and quality assessment was carried using the ARRIVE guidelines. Results: Nine animal studies were included in this review. In six studies, FGF-2 had a favorable effect on the tissue regeneration around roots of replanted teeth when compared to other treatment groups. However, quality assessment of the studies revealed many sources of bias and deficiencies in the studies. Conclusions: Within the limitations of this study, it may be concluded that FGF-2 may improve the outcomes of delayed replantation of avulsed teeth. However, more long-term animal studies, with improved experimental designs, and clinical trials are required to determine the clinical potential of the growth factor in improving the outcomes of delayed tooth replantation.<\/jats:p>","DOI":"10.1177\/00368504241228964","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T19:02:30Z","timestamp":1710529350000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of fibroblast growth factor-2 on the outcomes of tooth replantation: A systematic review of animal studies"],"prefix":"10.1177","volume":"107","author":[{"given":"Shariq","family":"Najeeb","sequence":"first","affiliation":[{"name":"Schulich School of Medicine and Dentistry, Western University, London, ON, Canada"},{"name":"Evidentia Dental Outcomes Research, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farwa Ali","family":"Manekia","sequence":"additional","affiliation":[{"name":"Karachi Medical and Dental College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-8490","authenticated-orcid":false,"given":"Muhammad Shahrukh Khan","family":"Sadiq","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Bahria University Dental College, Bahria University Health Ciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necdet","family":"Adanir","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, College of Dentistry, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-7335","authenticated-orcid":false,"given":"Zohaib","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Sohail","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, College of Dentistry, Taibah University, Al Madina Al Munawwarrah, Saudi Arabia"},{"name":"School of Dentistry, University of Jordan, Amman, Jordan"},{"name":"Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3205","authenticated-orcid":false,"given":"Artak","family":"Heboyan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Str. 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