{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:38:21Z","timestamp":1777901901138,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Patients with drug-related problems are at high risk for perioperative complications. The study aimed to determine the prevalence, number, characteristics, clinical significance and the involved drugs of drug-related problems in inpatients, who were admitted to elective surgery, as well as their burden of comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study design was a retrospective, observational study across nine different surgical sites. Patients at admission for elective surgery with \u2009\u2265\u20091 drug-related problem, a hospital stay of \u2009\u2265\u200924\u2005h and at age \u2009\u2265\u200918 years were included. The outcomes of interest were the prevalence and nature of drug-related problems, assessed by pharmacists at hospital admission. The Pharmaceutical Network Europe classification V9.1, the Hatoum scale of clinical significance, the Anatomical-Therapeutic-Chemical classification scheme of the World Health Organization were engaged to categorize drug-related problems and their clinical significance. The Charlson Comorbidity Index was applied to assess the comorbidity of participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The final data set included 11,176 elective surgical inpatients. Of these, a sample of 284 (2.54%) patients was analysed. It was found that 9.89% of the patients showed at least one drug-related problem (average 1.43, SD 0.7). Major causes were drug-drug interactions (30.3%) and supra-therapeutic doses (18.0%). Most drug-related problems were referred to a prescriber for intervention (61.3%). Eighty-two percent of drug-related problems were rated as clinically significant. Cardiovascular drugs were of major concern. Participants\u2019 most common comorbidities were tumour diagnosis (34%), diabetes mellitus with end organ damage (26%) and peripheral vascular diseases (19%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although the prevalence of drug-related problems in this diverse study population was low, drug-related problems were of great importance in terms of their cause and clinical significance. Patients with drug-related problems showed a moderate burden of physiological illness. Study results suggest a need to identify exposed patients with drug-related problems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504241263534","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T10:11:32Z","timestamp":1723025492000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Drug-related problems in elective surgical inpatients: A retrospective study"],"prefix":"10.1177","volume":"107","author":[{"given":"Clara","family":"Simon","sequence":"first","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University Salzburg, Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1681-4909","authenticated-orcid":false,"given":"Olaf","family":"Rose","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University Salzburg, Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Kanduth","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University Salzburg, Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Pachmayr","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University Salzburg, Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Clemens","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology and Clinical Pharmacy, Paracelsus Medical University Salzburg, Salzburg, Austria"},{"name":"Department of Anaesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"bibr1-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0696-7"},{"key":"bibr2-00368504241263534","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.16-5-481"},{"key":"bibr3-00368504241263534","doi-asserted-by":"publisher","DOI":"10.29252\/beat-070401"},{"key":"bibr4-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2013.05.006"},{"key":"bibr5-00368504241263534","first-page":"228","volume":"42","author":"Calvo-Salazar RA","year":"2018","journal-title":"Farm Hosp"},{"key":"bibr6-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2017.04.003"},{"key":"bibr7-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010003"},{"key":"bibr8-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0615-y"},{"key":"bibr9-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-012-0048-6"},{"key":"bibr10-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156304"},{"key":"bibr11-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2015.07.006"},{"key":"bibr12-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-066666"},{"key":"bibr13-00368504241263534","first-page":"741","volume":"113","author":"K\u00f6berlein-Neu J","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"bibr14-00368504241263534","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-020-01150-w"},{"key":"bibr15-00368504241263534","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr16-00368504241263534","unstructured":"Doyle DJ, Hendrix JM, Garmon EH. 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