{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:32:32Z","timestamp":1792409552992,"version":"4.4.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Patients with epistaxis typically visit the emergency department for initial treatment. According to recent studies, tranexamic acid (TXA) is effective in the treatment of epistaxis. This study compared the therapeutic superiority of saline to that of 500 and 1000\u2005mg doses of topical TXA for the treatment of anterior epistaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>This phase 4 clinical trial was a randomized, controlled, and double-blind trial. A total of 152 patients were divided into three groups. Group 1 was treated with 1000\u2005mg TXA, Group 2 with 500\u2005mg TXA, and Group 3 with saline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Based on multinomial logistic regression analysis, the bleeding frequency at the 5th minute was 2.9 times and rebleeding status was 4.3 times less in Group 1 (1000\u2005mg TXA) than in Group 3 (saline). There were no differences between the three groups in terms of side effects or salvage therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In addition to its superiority in treatment, 1000\u2005mg of TXA is recommended because of the decreased rate of recurrent bleeding and low incidence of side effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504241264993","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T04:32:15Z","timestamp":1727757135000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Appropriate dose of tranexamic acid in the topical treatment of anterior epistaxis, 500 mg vs 1000 mg:  A double-blind randomized controlled trial"],"prefix":"10.1177","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-5357","authenticated-orcid":false,"given":"C\u00fcneyt","family":"Arikan","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, \u0130zmir Ataturk Training and Research Hospital, Izmir, Turkey"},{"name":"Department of Emergency Medicine, Soma State Hospital, \rManisa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2477-1443","authenticated-orcid":false,"given":"P\u0131nar Ye\u015fim","family":"Akyol","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, \u0130zmir Ataturk Training and Research Hospital, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"bibr1-00368504241264993","first-page":"1322","volume-title":"Roberts and Hedges\u2019 clinical procedures in emergency medicine","author":"Riviello RJ","year":"2014","edition":"6"},{"key":"bibr2-00368504241264993","first-page":"305","volume":"71","author":"Kucik CJ","year":"2005","journal-title":"Am Fam Physician"},{"key":"bibr3-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0138-2"},{"key":"bibr4-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2004.12.014"},{"key":"bibr5-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001903861"},{"key":"bibr6-00368504241264993","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-2155"},{"key":"bibr7-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2013.06.043"},{"key":"bibr8-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2018.03.039"},{"key":"bibr9-00368504241264993","unstructured":"Tranexel 250 mg\/5 mL IV Solution for Injection Instructions for Use. Accessed February 23, 2023. https:\/\/titck.gov.tr\/storage\/Archive\/2020\/kubKtAttachments\/TTCKONAYLIKTTRANEXEL_b7199221-95ab-4caa-980c-66a9f87f357d.pdf."},{"key":"bibr10-00368504241264993","doi-asserted-by":"publisher","DOI":"10.3310\/hta17100"},{"key":"bibr11-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13345"},{"key":"bibr12-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.10.043"},{"key":"bibr13-00368504241264993","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01518"},{"key":"bibr14-00368504241264993","doi-asserted-by":"publisher","DOI":"10.3109\/00016487409129566"},{"key":"bibr15-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1159\/000276741"},{"key":"bibr16-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1988.tb00275.x"},{"key":"bibr17-00368504241264993","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010562"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241264993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504241264993","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241264993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:12:44Z","timestamp":1777633964000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504241264993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/00368504241264993"],"URL":"https:\/\/doi.org\/10.1177\/00368504241264993","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"article-number":"00368504241264993"}}