{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:35:01Z","timestamp":1784547301057,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Medical and Health Science and Technology Plan of Longgang Shenzhen","award":["LGKCYLWS2022019"],"award-info":[{"award-number":["LGKCYLWS2022019"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171160"],"award-info":[{"award-number":["82171160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sudden sensorineural hearing loss is a prevalent ear disorder requiring acute intervention, characterized by unclear etiology and challenging therapeutic interventions. This study aims to identify potential biomarkers for sudden sensorineural hearing loss through metabolomic profiling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed metabolomic data samples from a database associated with sensorineural hearing loss. Metabolomic analysis identified significantly differential metabolites in reversed-phase liquid chromatography and hydrophilic interaction liquid chromatography modes. We further validated abnormal metabolites using plasma samples from 51 sudden sensorineural hearing loss patients and 26 healthy controls in the case-control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Metabolomic analysis revealed 75 and 76 significantly differential metabolites in reversed-phase liquid chromatography and hydrophilic interaction liquid chromatography modes, respectively. Integrating metabolomic and transcriptomic analyses, we validated four abnormal metabolites\u2014triglyceride, lipase, S-adenosyl methionine, and cholesterol\u2014in our cohort. In the serum of patients with sudden sensorineural hearing loss, the contents of triglyceride, lipase, S-adenosyl methionine, and cholesterol were significantly increased. These metabolites demonstrated significant discriminatory potential in distinguishing sudden sensorineural hearing loss patients from healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings underscore the promising utility of metabolomic profiling as a valuable approach for identifying potential biomarkers and unraveling the underlying mechanisms of sudden sensorineural hearing loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504241277745","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T21:11:32Z","timestamp":1763068292000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabolomic profiling reveals potential biomarkers for sudden sensorineural hearing loss"],"prefix":"10.1177","volume":"108","author":[{"given":"Xintao","family":"Wang","sequence":"first","affiliation":[{"name":"Ganzhou, Jiangxi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Huang","sequence":"additional","affiliation":[{"name":", Sun Yat-sen Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-6313","authenticated-orcid":false,"given":"Huasong","family":"Zhang","sequence":"additional","affiliation":[{"name":", Sun Yat-sen Memorial Hospital"},{"name":"; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Third Affiliated Hospital, Guangzhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Ou","sequence":"additional","affiliation":[{"name":", Sun Yat-sen Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suijun","family":"Chen","sequence":"additional","affiliation":[{"name":", Sun Yat-sen Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Clinical practice guideline: sudden hearing loss (update)","volume":"161","author":"Chandrasekhar SS","year":"2019","unstructured":"Chandrasekhar SS, Tsai Do BS, Schwartz SR, et al. Clinical practice guideline: sudden hearing loss (update). 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