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The passive immunization of the fetus by NLS-causing maternal antibodies may occur in the absence of a previously known maternal systemic autoimmune rheumatic disease (SARD). Screening for NLS-related antibodies in patients with related SARD or those in whom there is a risk of NLS including first-degree relatives should occur before pregnancy. This screening is best performed as part of a collaborative relationship between obstetrics and rheumatology. Pregnancy preparations in those with SARD include transitioning to pregnancy-safe medications. The symptoms of NLS range from minor skin rashes to fetal demise from heart block. Fetal screening allows for maternal therapeutic interventions that may be beneficial, as well as the use of fetal pacemakers in the more severe cases that include cardiac NLS.<\/jats:p>","DOI":"10.1177\/00368504241278476","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T15:42:21Z","timestamp":1726587741000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["A review of neonatal lupus syndrome"],"prefix":"10.1177","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6464-5367","authenticated-orcid":false,"given":"Adegbenga","family":"Bankole","sequence":"first","affiliation":[{"name":"Internal Medicine\/Rheumatology, Virginia Tech Carilion School of Medicine (VTCSOM), Roanoke, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Nwaonu","sequence":"additional","affiliation":[{"name":"Internal Medicine\/Rheumatology, 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