{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:26:42Z","timestamp":1780550802220,"version":"3.54.1"},"reference-count":49,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Science and Technology Program of Jiangxi Health Commission","award":["202410094"],"award-info":[{"award-number":["202410094"]}]},{"name":"the Bureau of Science and Technology of Ganzhou Municipality Research Foundation","award":["GZ2023ZSF014"],"award-info":[{"award-number":["GZ2023ZSF014"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The primary treatment for varicose ulcers is to address the underlying cause of venous hypertension, additionally, split-thickness skin transplantation (ST) is an effective option for large ulcers. The aim of this study was to compare the efficacy of venous surgery with or without split-thickness ST in the management of varicose ulcers (diameter \u22656\u2005cm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with varicose ulcers between 2013 and 2023 were included in the real-world retrospective cohort study. The endovenous microwave ablation\/endovenous laser ablation-high ligation-foam sclerotherapy-compression therapy\u2009+\u2009ST group (EMA\/EVLA-CT-HL-FS\u2009+\u2009ST) consisted of 32 patients, while the EMA\/EVLA-CT-HL-FS group consisted of 48 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A difference in ulcer healing time was found between the two groups (the hazard ratio [HR] was 4.4, 95% CI [2.3\u20138.2], P\u2009&lt;\u20090.0001). However, the healing rate did not differ between the two groups at 6 and 12 months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ST has been shown to expedite ulcer healing and ameliorate the symptoms of VVs in the early stages of treatment, while its intermediate to long-term efficacy for ulcer healing and overall patient quality of life may be limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504241283352","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T02:35:19Z","timestamp":1726626919000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the effect  of combination therapies in  the treatment of large  varicose ulcers: A real-world cohort study"],"prefix":"10.1177","volume":"107","author":[{"given":"Fangfang","family":"Wen","sequence":"first","affiliation":[{"name":"The Department of General Surgery, Ganzhou People's Hospital, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Xie","sequence":"additional","affiliation":[{"name":"The Department of General Surgery, Ganzhou People's Hospital, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minggui","family":"Lai","sequence":"additional","affiliation":[{"name":"The Department of General Surgery, Ganzhou People's Hospital, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofu","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Department of General Surgery, Ganzhou People's Hospital, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuancai","family":"Xie","sequence":"additional","affiliation":[{"name":"The Department of General Surgery, Ganzhou People's Hospital, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-2328","authenticated-orcid":false,"given":"Xiaochun","family":"Liu","sequence":"additional","affiliation":[{"name":"The Department of General Surgery, Ganzhou People's Hospital, Ganzhou, Jiangxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"bibr1-00368504241283352","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12196153"},{"key":"bibr2-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13333"},{"key":"bibr3-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2014.04.006"},{"key":"bibr4-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.049"},{"key":"bibr5-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1177\/17085381211011356"},{"key":"bibr6-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1177\/17085381221094884"},{"key":"bibr7-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.07.004"},{"key":"bibr8-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13293"},{"key":"bibr9-00368504241283352","volume":"2016","author":"Nelson EA","year":"2016","journal-title":"BMJ Clin Evid"},{"key":"bibr10-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025597"},{"key":"bibr11-00368504241283352","volume":"2013","author":"Jones JE","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr12-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1177\/0268355516689631"},{"key":"bibr13-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14390"},{"key":"bibr14-00368504241283352","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.10.615"},{"key":"bibr15-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000369"},{"key":"bibr16-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1177\/17085381221099115"},{"key":"bibr17-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1258\/phleb.2011.011147"},{"key":"bibr18-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2020.04.019"},{"key":"bibr19-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2021.12.024"},{"key":"bibr20-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1177\/0268355519857362"},{"key":"bibr21-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2020.11.012"},{"key":"bibr22-00368504241283352","volume":"8","author":"Whing J","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr23-00368504241283352","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1022439"},{"key":"bibr24-00368504241283352","doi-asserted-by":"publisher","DOI":"10.2340\/0001555574310311"},{"key":"bibr25-00368504241283352","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr26-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50617-y"},{"key":"bibr27-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.11.025"},{"key":"bibr28-00368504241283352","author":"Zheng G","journal-title":"Postgrad Med"},{"key":"bibr29-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.04.017"},{"key":"bibr30-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.05.117"},{"key":"bibr31-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2011.04.008"},{"key":"bibr32-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1988.tb00638.x"},{"key":"bibr33-00368504241283352","first-page":"222","volume":"77","author":"Wood MK","year":"1995","journal-title":"Ann R Coll Surg Engl"},{"key":"bibr34-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12575"},{"key":"bibr35-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000137"},{"key":"bibr36-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80999-1"},{"key":"bibr37-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2015.07.003"},{"key":"bibr38-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2022.11.005"},{"key":"bibr39-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.06.035"},{"key":"bibr40-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-023-03833-y"},{"key":"bibr41-00368504241283352","volume":"99","author":"Liu X","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"bibr42-00368504241283352","volume":"12","author":"Li Y","year":"2022","journal-title":"BMJ Open"},{"key":"bibr43-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1177\/0268355515589536"},{"key":"bibr44-00368504241283352","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-9590.17.03827-5"},{"key":"bibr45-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2019.09.016"},{"key":"bibr46-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.05.011"},{"key":"bibr47-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2018.05.008"},{"key":"bibr48-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)90852-6"},{"key":"bibr49-00368504241283352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.04.058"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241283352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504241283352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241283352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:13:31Z","timestamp":1777634011000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504241283352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/00368504241283352"],"URL":"https:\/\/doi.org\/10.1177\/00368504241283352","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"article-number":"00368504241283352"}}