{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:38:56Z","timestamp":1777901936445,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016917","name":"Scottish Enterprise","doi-asserted-by":"publisher","award":["00\/0028"],"award-info":[{"award-number":["00\/0028"]}],"id":[{"id":"10.13039\/100016917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this feasibility study, firstly, we aimed to assess whether intramuscular pH (IMpH) could be measured with a glass-tipped electrode. Secondly, we aimed to explore whether we could monitor changes in skeletal muscle pH before and throughout static (isometric) and after dynamic (treadmill) exercise, comparing individuals with intermittent claudication (IC) to a group of healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty participants with IC (mean age\u2009\u00b1\u2009SD) 68\u2009\u00b1\u20098) and 40 healthy volunteers (63\u2009\u00b1\u200910) were recruited. Participants in the IC group had an ankle brachial pressure index of &lt;0.7 (mean: 0.62\u2009\u00b1\u20090.13). The first 20 participants in each group underwent isometric ankle dorsiflexion for 120\u2005s at 30% of maximum voluntary contraction and the remainder underwent treadmill exercise (3.6 km\/h, 5\u00b0 incline) to maximal walking distance. A sterilised reusable 1.5 mm shatterproof, heat strengthened glass tipped pH probe inserted using a peripheral venous cannula and in combination with a pH meter was used to measure IMpH of the tibialis anterior muscle prior to, during and continuously for 1\u2005h after exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Resting IMpH was similar between the groups (median 6.8 (interquartile range (IQR) 6.7-6.9)) for IC individuals and 6.7 (6.6 to 6.8) for controls). Following isometric exercise, the magnitude of the decrease in IMpH was greatest in the IC group (median \u0394pH max. in patients \u22120.2 (IQR: \u22120.2 to \u22120.1) versus \u22120.1 (IQR: \u22120.2 to \u22120.1) in the control group ( p\u2009=\u20090.002). After treadmill exercise, the magnitude of the decrease in IMpH (\u0394pH max) was greatest in individuals with IC (median \u0394pH max. in patients \u22120.3 (IQR: \u22120.3 to \u22120.3) versus 0 (IQR: \u22120.2 to 0) in the control group, p\u2009=\u20090.04.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IMpH monitoring with a flexible glass probe inserted into the tibialis anterior muscle is viable and changes in IMpH during static and dynamic exercises are detected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504241292126","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T19:26:29Z","timestamp":1736969189000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intramuscular pH monitoring before and during exercise in individuals with intermittent claudication compared to healthy controls: A feasibility study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6223-9488","authenticated-orcid":false,"given":"Andrew D.","family":"Ablett","sequence":"first","affiliation":[{"name":"Department of Trauma and Orthopaedics, Aberdeen Royal Infirmary, NHS Lothian, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of General Surgery, NHS Dumfries and Galloway, Dumfries, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Ball","sequence":"additional","affiliation":[{"name":"Institute of Education in Medical and Dental Sciences,  University of Aberdeen, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Brittenden","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, NHS Grampian, Aberdeen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"bibr1-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198310000-00013"},{"key":"bibr2-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2008.01840.x"},{"key":"bibr3-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199312000-00011"},{"key":"bibr4-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1038\/srep32037"},{"key":"bibr5-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33297-5"},{"key":"bibr6-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(85)80630-2"},{"key":"bibr7-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05863-y"},{"key":"bibr8-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1139\/h04-031"},{"key":"bibr9-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"bibr10-00368504241292126","first-page":"499","volume":"21","author":"Fontaine R","year":"1954","journal-title":"Helv Chir Acta"},{"key":"bibr11-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.106.BJR-2020-0469.R1"},{"key":"bibr12-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1097\/OI9.0000000000000248"},{"key":"bibr13-00368504241292126","volume-title":"Assessing the severity of lower limb ischaemia and the thrombo-inflammatory response to surgery and exercise in peripheral arterial disease","author":"Collins PWH","year":"2008"},{"key":"bibr14-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019480"},{"key":"bibr15-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2008.00801.x"},{"key":"bibr16-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.04.042"},{"key":"bibr17-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.5.2194"},{"key":"bibr18-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2003.07.001"},{"key":"bibr19-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.012954"},{"key":"bibr20-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1007\/BF00236292"},{"key":"bibr21-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.3.E400"},{"key":"bibr22-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199711000-00001"},{"key":"bibr23-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.175.2.2326464"},{"key":"bibr24-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.106421"},{"key":"bibr25-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.117152"},{"key":"bibr26-00368504241292126","first-page":"1","volume":"455","author":"Sahlin K","year":"1978","journal-title":"Acta Physiol Scand Suppl"},{"key":"bibr27-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1007\/BF00585149"},{"key":"bibr28-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00303.2003"},{"key":"bibr29-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1016\/S1520-765X(02)90015-5"},{"key":"bibr30-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.49.4.649"},{"key":"bibr31-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1972.33.2.199"},{"key":"bibr32-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.4.831"},{"key":"bibr33-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.275.1.E132"},{"key":"bibr34-00368504241292126","volume":"12","author":"Lane R","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr35-00368504241292126","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2017.0216"},{"key":"bibr36-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpsur.2018.12.007"},{"key":"bibr37-00368504241292126","doi-asserted-by":"publisher","DOI":"10.1159\/000157968"},{"key":"bibr38-00368504241292126","first-page":"187","volume":"150","author":"Matsen III FA","year":"1980","journal-title":"Clin Orthop Relat Res"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241292126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504241292126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241292126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:13:48Z","timestamp":1777634028000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504241292126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/00368504241292126"],"URL":"https:\/\/doi.org\/10.1177\/00368504241292126","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"00368504241292126"}}