{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:19:11Z","timestamp":1792185551388,"version":"4.4.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["12126602"],"award-info":[{"award-number":["12126602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["42107465"],"award-info":[{"award-number":["42107465"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82030102"],"award-info":[{"award-number":["82030102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"R&D project of Pazhou Lab","award":["2023K0610"],"award-info":[{"award-number":["2023K0610"]}]},{"name":"Shenzhen Medical Academy of Research and Translation","award":["C2302001"],"award-info":[{"award-number":["C2302001"]}]},{"name":"Ministry of Science and Technology of China","award":["2022YFC3702703"],"award-info":[{"award-number":["2022YFC3702703"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Benzodiazepines (BZDs) are commonly prescribed as adjunctive drugs for patients with cardiovascular diseases (CVDs), particularly those who experience anxiety or insomnia. However, the relationship between the use of BZDs and incident risk of sudden cardiac arrest (SCA) has not been well investigated. In this study, we aimed to examine the association between the use of BZDs and the incident risk of SCA among patients with CVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In this retrospective cohort study, a total of 74,715 eligible patients with new-onset CVD as a primary cause of hospitalization between July 2016 and August 2022 were included from the health information platform in Shenzhen, China. Among them, 61,761 BZD non-initiators were identified and matched to 12,954 BZD initiators by propensity score at a maximum ratio of 5:1. Propensity score-matched Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a 12-month follow-up period, 29 (2.24 per 1000 person-years) and 137 (2.22 per 1000 person-years) SCA cases occurred among propensity score-matched BZD initiators and non-initiators, respectively. Patients who initiated BZD treatment were associated with a 101% increased risk of SCA incidence compared with patients without BZD treatment (adjusted HR: 2.01, 95% CI: 1.42, 2.83). Furthermore, compared with the non-use (0 defined daily dose, DDD), the adjusted HR was 1.43 (95% CI: 1.32, 1.56) for the BZD consumption of \u22641 DDD and 2.58 (95% CI: 2.37, 2.81) for the BZD consumption of &gt;1 DDD ( P for trend\u2009&lt;\u20090.001) within a 12-month follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides evidence that BZD initiation may be associated with an increased incident risk of SCA in patients with CVD. Our finding highlights the importance of cautious prescribing BZDs in the health management of patients with CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504241295325","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T02:04:12Z","timestamp":1730685852000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Benzodiazepine use and incident risk of sudden cardiac arrest in patients with cardiovascular diseases"],"prefix":"10.1177","volume":"107","author":[{"given":"Chunbao","family":"Mo","sequence":"first","affiliation":[{"name":"School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China"},{"name":"Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Health Development Research and Data Management Center, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China"},{"name":"Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China"},{"name":"Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China"},{"name":"Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China"},{"name":"Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolong","family":"Pei","sequence":"additional","affiliation":[{"name":"School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China"},{"name":"Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shenzhen Health Development Research and Data Management Center, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchao","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen, China"},{"name":"Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"bibr1-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.976092"},{"key":"bibr2-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.01.007"},{"key":"bibr3-00368504241295325","first-page":"1005","volume":"38","year":"2023","journal-title":"Chinese Circulation Journal"},{"key":"bibr4-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(23)00173-1"},{"key":"bibr5-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv143"},{"key":"bibr6-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2019.04.006"},{"key":"bibr7-00368504241295325","first-page":"669","volume":"36","author":"The WCOT","year":"2023","journal-title":"Biomed Environ Sci"},{"key":"bibr8-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2013.03.010"},{"key":"bibr9-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.01.026"},{"key":"bibr10-00368504241295325","doi-asserted-by":"publisher","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_42_22"},{"key":"bibr11-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-016-0800-3"},{"key":"bibr12-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.10.002"},{"key":"bibr13-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90185-1"},{"key":"bibr14-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2007.00343.x"},{"key":"bibr15-00368504241295325","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58030409"},{"key":"bibr16-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199507000-00008"},{"key":"bibr17-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-018-2515-4"},{"key":"bibr18-00368504241295325","doi-asserted-by":"publisher","DOI":"10.26599\/1671-5411.2024.01.005"},{"key":"bibr19-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcrp.2024.200317"},{"key":"bibr20-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.07.024"},{"key":"bibr21-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-016-0404-x"},{"key":"bibr22-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"bibr23-00368504241295325","unstructured":"The European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP). Guide on Methodological Standards in Pharmacoepidemiology (Revision 10). EMA\/95098\/2010."},{"key":"bibr24-00368504241295325","volume":"358","author":"Patorno E","year":"2017","journal-title":"Br Med J"},{"key":"bibr25-00368504241295325","first-page":"1339","volume":"165","author":"Montori VM","year":"2001","journal-title":"CMAJ"},{"key":"bibr26-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"bibr27-00368504241295325","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S241610"},{"key":"bibr28-00368504241295325","first-page":"2875","volume":"135","author":"Wang C","year":"2022","journal-title":"Chinese Med J-Peking"},{"key":"bibr29-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab158"},{"key":"bibr30-00368504241295325","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment 2023. Oslo, Norway, 2022."},{"key":"bibr31-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115553"},{"key":"bibr32-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1677-y"},{"key":"bibr33-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1763"},{"key":"bibr34-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2010.03.008"},{"key":"bibr35-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112598"},{"key":"bibr36-00368504241295325","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2018.29.2"},{"key":"bibr37-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5861"},{"key":"bibr38-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000161"},{"key":"bibr39-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.07.006"},{"key":"bibr40-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15050618"},{"key":"bibr41-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1997.tb03692.x"},{"key":"bibr42-00368504241295325","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2019.12.09"},{"key":"bibr43-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90282-I"},{"key":"bibr44-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00128412"},{"key":"bibr45-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21064-y"},{"key":"bibr46-00368504241295325","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90017-9"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241295325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504241295325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241295325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:13:54Z","timestamp":1777634034000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504241295325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/00368504241295325"],"URL":"https:\/\/doi.org\/10.1177\/00368504241295325","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"article-number":"00368504241295325"}}