{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:26:20Z","timestamp":1783967180504,"version":"3.55.0"},"reference-count":91,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>Melatonin, N-acetyl-5-methoxytryptamine, is a neuroendocrine hormone secreted by the pineal gland. This pleiotropic indoleamine possesses amphiphilic properties, allowing it to penetrate most biological barriers and exert its effects at the subcellular level. Importantly, melatonin also plays a crucial role in regulating the body's response to circadian rhythms, adapting to internal and external environmental cues. Melatonin functions as a powerful antioxidant and free radical scavenger, protecting cells from oxidative damage. Its diverse physiological roles include maintaining the functional integrity of endothelial cells, thereby preventing atherosclerosis, a major contributor to cardiovascular disease. Additionally, melatonin exhibits antioxidant and free radical scavenging properties, potentially improving metabolic disorders. These combined effects suggest a unique adjunctive therapeutic potential for melatonin in treating cardiovascular diseases. This review aims to explore the mechanisms by which melatonin interacts with the cardiovascular system and investigates its potential use as an adjunctive therapeutic agent in managing cardiovascular disease.<\/jats:p>","DOI":"10.1177\/00368504241299993","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T03:54:46Z","timestamp":1732247686000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Melatonin as an adjunctive therapy in cardiovascular disease management"],"prefix":"10.1177","volume":"107","author":[{"given":"Zan","family":"Luo","sequence":"first","affiliation":[{"name":"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Yuan","family":"Tang","sequence":"additional","affiliation":[{"name":"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1996-3088","authenticated-orcid":false,"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Clinical Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"bibr1-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.308903"},{"key":"bibr2-00368504241299993","first-page":"139","volume":"176","author":"Bijukumar DR","year":"2018","journal-title":"Physiol Behav"},{"key":"bibr3-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030530"},{"key":"bibr4-00368504241299993","first-page":"173","volume":"22","author":"Souissi A","year":"2023","journal-title":"EXCLI J"},{"key":"bibr5-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-014-2351-z"},{"key":"bibr6-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-024-00631-x"},{"key":"bibr7-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052919"},{"key":"bibr8-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-59786-x"},{"key":"bibr9-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106072"},{"key":"bibr10-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241511931"},{"key":"bibr11-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12855"},{"key":"bibr12-00368504241299993","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s41073-019-0064-8","volume":"4","author":"Baethge C","year":"2019","journal-title":"Res Integr Peer Rev"},{"key":"bibr13-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2956-z"},{"key":"bibr14-00368504241299993","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7502"},{"key":"bibr15-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.11.005"},{"key":"bibr16-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2023.2288272"},{"key":"bibr17-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239232"},{"key":"bibr18-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5284728"},{"key":"bibr19-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000785"},{"key":"bibr20-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-004-1298-5"},{"key":"bibr21-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000092890.29552.22"},{"key":"bibr22-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9676-1"},{"key":"bibr23-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2003.00083.x"},{"key":"bibr24-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043259"},{"key":"bibr25-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1076116"},{"key":"bibr26-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2002.01890.x"},{"key":"bibr27-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12961"},{"key":"bibr28-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmz070"},{"key":"bibr29-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00955.x"},{"key":"bibr30-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1159\/000046904"},{"key":"bibr31-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1113\/eph8602205"},{"key":"bibr32-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00094.2013"},{"key":"bibr33-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14046981"},{"key":"bibr34-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.08.013"},{"key":"bibr35-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/nu15092202"},{"key":"bibr36-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.637793"},{"key":"bibr37-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/biom10121702"},{"key":"bibr38-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12847"},{"key":"bibr39-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052809"},{"key":"bibr40-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.016"},{"key":"bibr41-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10050796"},{"key":"bibr42-00368504241299993","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0956"},{"key":"bibr43-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00756.x"},{"key":"bibr44-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2006.00270.x"},{"key":"bibr45-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12257"},{"key":"bibr46-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00573-1"},{"key":"bibr47-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.02.066"},{"key":"bibr48-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.08.014"},{"key":"bibr49-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071473"},{"key":"bibr50-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010358"},{"key":"bibr51-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx261"},{"key":"bibr52-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0301-z"},{"key":"bibr53-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3390\/life14010088"},{"key":"bibr54-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2012.01001.x"},{"key":"bibr55-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.11.033"},{"key":"bibr56-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/703175"},{"key":"bibr57-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12190"},{"key":"bibr58-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"key":"bibr59-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1177\/0748730413489957"},{"key":"bibr60-00368504241299993","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-20314-w","volume":"12","author":"Hayter EA","year":"2021","journal-title":"Nat Commun"},{"key":"bibr61-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1038\/nature10852"},{"key":"bibr62-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.888319"},{"key":"bibr63-00368504241299993","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00366"},{"key":"bibr64-00368504241299993","doi-asserted-by":"crossref","unstructured":"Benova T, Viczenczova C, Radosinska J, et al. Maladaptation of connexin-43 and propensity of the heart to lethal. 2013; 639: 633\u2013639.","DOI":"10.1139\/cjpp-2012-0393"},{"key":"bibr65-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14116"},{"key":"bibr66-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-019-09689-7"},{"key":"bibr67-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03765-x"},{"key":"bibr68-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601320200"},{"key":"bibr69-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00535.x"},{"key":"bibr70-00368504241299993","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266253465230920114223"},{"key":"bibr71-00368504241299993","first-page":"577","volume":"36","author":"Kravchenko KP","year":"2323","journal-title":"Adv Gerontol"},{"key":"bibr72-00368504241299993","first-page":"1101","volume":"19","author":"Balli E","year":"2004","journal-title":"Histol Histopathol"},{"key":"bibr73-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117173"},{"key":"bibr74-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.02.002"},{"key":"bibr75-00368504241299993","first-page":"577","volume":"7","author":"Grossman E","year":"2011","journal-title":"Vasc Health Risk Manag"},{"key":"bibr76-00368504241299993","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.physbeh.2017.03.040","volume":"176","author":"Kristi LS","year":"2017","journal-title":"Physiol Behav"},{"key":"bibr77-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2004.07.001"},{"key":"bibr78-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231379"},{"key":"bibr79-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2676-11.2011"},{"key":"bibr80-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1031"},{"key":"bibr81-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2590"},{"key":"bibr82-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-014-0178-0"},{"key":"bibr83-00368504241299993","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6434"},{"key":"bibr84-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3249"},{"key":"bibr85-00368504241299993","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645100-00005"},{"key":"bibr86-00368504241299993","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7122a1"},{"key":"bibr87-00368504241299993","unstructured":"Sundhedsstyrrelsen.\n                      Behandling Med Melatonin Ved S\u00f8vnforstyrrelser Hos B\u00f8rn Og Unge\n                      . 2022."},{"key":"bibr88-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2020.1822532"},{"key":"bibr89-00368504241299993","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6462"},{"key":"bibr90-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12189"},{"key":"bibr91-00368504241299993","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-015-0368-5"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241299993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504241299993","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241299993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:14:03Z","timestamp":1777634043000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504241299993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":91,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/00368504241299993"],"URL":"https:\/\/doi.org\/10.1177\/00368504241299993","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"article-number":"00368504241299993"}}