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However, cases invading the pterygopalatine fossa are extremely rare. In this article, we describe a rare case of a man in his early 60s who presented with left nasal congestion, headache, epistaxis, and facial numbness. The patient underwent a comprehensive treatment primarily based on surgery. Nasal endoscopy showed that the mass had invaded the left infratemporal fossa laterally and was poorly separated from the internal maxillary artery, which increased the complexity and difficulty of the surgery. In addition, the patient had previously undergone nasal cavity surgery, which made the surgery more challenging. In order to reduce the risk of recurrence, we exposed the infratemporal fossa region under nasal endoscopic guidance with a combined labial and gingival incision, and completely removed the tumor base and tumor margins. There were no postoperative complications and no recurrence was observed during the 2-year follow-up period.<\/jats:p>","DOI":"10.1177\/00368504241306895","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T02:42:14Z","timestamp":1734662534000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatments in sinonasal inverted papilloma malignancy invading the pterygopalatine fossa: A case report"],"prefix":"10.1177","volume":"107","author":[{"given":"Linlan","family":"Jiang","sequence":"first","affiliation":[{"name":"Guangzhou Twelfth People's Hospital, Guangzhou, China"},{"name":"Institute of Otorhinolarngology, Head and Neck Surgery, Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5797-4490","authenticated-orcid":false,"given":"Liwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou Twelfth People's Hospital, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyi","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangzhou Twelfth People's Hospital, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuenong","family":"Jiao","sequence":"additional","affiliation":[{"name":"Guangzhou Twelfth People's Hospital, Guangzhou, China"},{"name":"Institute of Otorhinolarngology, Head and Neck Surgery, Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huicheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Guangzhou Twelfth People's Hospital, Guangzhou, China"},{"name":"Institute of Otorhinolarngology, Head and Neck Surgery, Guangzhou Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"bibr1-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1177\/00368504241248004"},{"key":"bibr2-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"bibr3-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22495"},{"key":"bibr4-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.11.005"},{"key":"bibr5-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0818-9"},{"key":"bibr6-00368504241306895","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14752"},{"key":"bibr7-00368504241306895","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6089"},{"key":"bibr8-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1177\/0145561320988366"},{"key":"bibr9-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.02.007"},{"key":"bibr10-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2008.02.005"},{"key":"bibr11-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2021.04.008"},{"key":"bibr12-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20211374"},{"key":"bibr13-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2604-z"},{"key":"bibr14-00368504241306895","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903311211"},{"key":"bibr15-00368504241306895","doi-asserted-by":"publisher","DOI":"10.1177\/01455613211068567"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241306895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504241306895","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504241306895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:14:29Z","timestamp":1777634069000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504241306895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/00368504241306895"],"URL":"https:\/\/doi.org\/10.1177\/00368504241306895","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"article-number":"00368504241306895"}}