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Most of such lncRNAs show similar dysregulation patterns when the two types of tumors are compared, suggesting that these aberrations are characteristic features of these liver tumor types. In the present study, we aimed to identify some candidate lncRNAs that are associated specifically with CCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      According to The Cancer Genome Atlas data, we chose\n                      <jats:italic toggle=\"yes\">LINC00941<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">ABHD11-AS1<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">CASC8<\/jats:italic>\n                      as promising biomarkers dysregulated in CCA but unaffected in HCC. We first verified their upregulation in an existing transcriptomic dataset for CCA patients. Next, we estimated expression levels of these three lncRNAs by reverse-transcription quantitative PCR in a group of paired (tumorous\/adjacent) postsurgery tissue samples from 110 patients with various liver lesions: CCA, HCC, combined HCC-CCA, or benign liver tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant upregulation of\n                      <jats:italic toggle=\"yes\">LINC00941<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">ABHD11-AS1<\/jats:italic>\n                      was noted in most of the investigated CCA samples, whereas in HCC samples, increased expression of these two lncRNAs was observed only in some types of cases (mainly characterized by an advanced tumor stage). In contrast,\n                      <jats:italic toggle=\"yes\">CASC8<\/jats:italic>\n                      manifested extremely low expression and no diagnostic potential in all the tested liver samples. Analyzing expression correlations of lncRNAs with candidate genes, we obtained strong evidence for\n                      <jats:italic toggle=\"yes\">LINC00941<\/jats:italic>\n                      -mediated upregulation of\n                      <jats:italic toggle=\"yes\">CAPRIN2<\/jats:italic>\n                      in CCA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      For the first time, we show the upregulation of\n                      <jats:italic toggle=\"yes\">LINC00941<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">ABHD11-AS1<\/jats:italic>\n                      in CCA and report their good potential as diagnostic biomarkers for this type of liver tumor.\n                    <\/jats:p>\n                  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