{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:39:33Z","timestamp":1777901973764,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to assess the ability of plasma InterLeukin-6 (IL-6) monitoring to predict the failure to switch from volume-controlled ventilation to spontaneous ventilation (SV) in patients with COVID-19-related acute respiratory distress syndrome (ARDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an observational, single-center and prospective cohort study in the medico-surgical intensive care unit of Avignon Hospital Center. Participants were adult patients requiring invasive mechanical ventilation for COVID-19-related ARDS between August 2021 and August 2022, who were eligible for switching from volume-controlled ventilation to SV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 35 patients included in the study, 13 (37%) successfully switched from controlled ventilation to SV, while 22 failed (63%). In the failure group, mean plasma IL-6 levels were higher than in the successful group from hour 0 (defined as the moment of the switch to SV mode) to 48\u2005h. However, differences between groups became significant from 24\u2005h (362.8 vs. 33.6 pg\/mL, P\u2009=\u20090.002). Interestingly, between-group differences in plasma C-reactive protein (CRP) levels were only significant between groups from 48\u2005h (129.3 vs. 52.2 mg\/L, P\u2009=\u20090.017). Finally, IL-6 and CRP had a similar ability to predict the failure to switch to SV mode: area under the receiving operative curves 0.763 [95%CI: 0.633-0.893] and 0.753 [95%CI: 0.595-0.911], respectively (P\u2009=\u20090.87).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL-6 and CRP are inflammatory biomarkers predictive of failure to switch to SV mode in COVID-19 ARDS patients. Our results showed that IL-6 can detect failure earlier than CRP. However, larger multicenter studies are needed to confirm our results, particularly in other ARDS models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251335850","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T04:20:34Z","timestamp":1744863634000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of InterLeukin-6 monitoring during weaning from volume-controlled ventilation in patients with COVID-19 acute respiratory distress syndrome"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2201-3115","authenticated-orcid":false,"given":"Estelle","family":"Delaunay","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Henri Duffaut Avignon General Hospital, Avignon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Poussard","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Henri Duffaut Avignon General Hospital, Avignon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9raud","family":"Gourjon","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Henri Duffaut Avignon General Hospital, Avignon, France"},{"name":"SCientific and Osteopathic Research Department, Institut de Formation en Ost\u00e9opathie du Grand Avignon (IFO-GA), Avignon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Frouin","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Henri Duffaut Avignon General Hospital, Avignon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Ducq","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Henri Duffaut Avignon General Hospital, Avignon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Di Vico","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Henri Duffaut Avignon General Hospital, Avignon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Moschietto","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Henri Duffaut Avignon General Hospital, Avignon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romaric","family":"Larcher","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Henri Duffaut Avignon General Hospital, Avignon, France"},{"name":"PhyMedExp, French National Health and Medical Research Body (INSERM), National Centre for Scientific Research (CNRS), Montpellier University, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-6218","authenticated-orcid":false,"given":"Ga\u00ebl","family":"Pradel","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Henri Duffaut Avignon General Hospital, Avignon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"Besnard X Demaison C Dugu\u00e9 A et al. France portrait social. Insee R\u00e9f\u00e9rences. Issue 2021 pp 1-57. Available at: https:\/\/www.insee.fr. Accessed November 11 2021."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.026"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066610395678"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0540-9"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00676-0"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1004023"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00798-x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001814"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202005-1951OC"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.4.1062"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1081CP"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50674"},{"key":"e_1_3_4_16_2","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"ARDS Definition Task Force","year":"2012","unstructured":"ARDS Definition Task Force; Ranieri VM, Rubenfeld GB, Thompson BT, et al. Acute respiratory distress syndrome: the Berlin definition. JAMA 2012; 307: 2526\u20132533.","journal-title":"JAMA"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510240069035"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3821"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.5_Pt_1.1121"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05950-6"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad195"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13546-010-0026-4"},{"key":"e_1_3_4_24_2","unstructured":"Jaber S Jung B Coisel Y et al. Les nouveaux modes ventilatoires utilisant des boucles automatis\u00e9es dans le sevrage ventilatoire. In: MAPAR Editions. Protocoles MAPAR 2012. 2012 pp 385-399."},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000968"},{"key":"e_1_3_4_26_2","article-title":"Successful versus failed transition from controlled ventilation to pressure support ventilation in COVID-19 patients: a retrospective cohort study","volume":"8","author":"Friz MP","year":"2024","unstructured":"Friz MP, Rezoagli E, Fakhr BS, et al. Successful versus failed transition from controlled ventilation to pressure support ventilation in COVID-19 patients: a retrospective cohort study. Crit Care Explor 2024; 8: e1039.","journal-title":"Crit Care Explor"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.03.019"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.17"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2000.147"},{"key":"e_1_3_4_30_2","first-page":"263","article-title":"Procalcitonin: experience with a new diagnostic tool for bacterial infection and systemic inflammation","volume":"23","author":"Meisner M","year":"1999","unstructured":"Meisner M. Procalcitonin: experience with a new diagnostic tool for bacterial infection and systemic inflammation. J Lab Med 1999; 23: 263\u2013272.","journal-title":"J Lab Med"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199204000-00009"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198910000-00001"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-009-0003-0"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000172614.36571.75"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(97)89552-9"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-007-7077-9"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103026"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102763"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.008"},{"key":"e_1_3_4_41_2","first-page":"7401","article-title":"Higher serum procalcitonin and IL-6 levels predict worse diagnosis for acute respiratory distress syndrome patients with multiple organ dysfunction","volume":"10","author":"Hui L","year":"2017","unstructured":"Hui L, Zhang X, An X, et al. Higher serum procalcitonin and IL-6 levels predict worse diagnosis for acute respiratory distress syndrome patients with multiple organ dysfunction. Int J Clin Exp Pathol 2017; 10: 7401\u20137407.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60331"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30127-2"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17052"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00037511"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00010206"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/08850666221095436"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1159\/000525604"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc9296"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251335850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504251335850","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251335850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:15:41Z","timestamp":1777634141000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504251335850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/00368504251335850"],"URL":"https:\/\/doi.org\/10.1177\/00368504251335850","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"article-number":"00368504251335850"}}