{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:33:36Z","timestamp":1788561216219,"version":"build-2803163510"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010628","name":"Universidad de La Sabana","doi-asserted-by":"publisher","award":["MEDEsp-107-2023"],"award-info":[{"award-number":["MEDEsp-107-2023"]}],"id":[{"id":"10.13039\/501100010628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Group 1 pulmonary arterial hypertension (PAH) causes increased vascular resistance, right heart failure, and reduced survival. High-altitude PAH survival data are limited despite chronic hypoxia's potential impact on disease progression and risk stratification. The objective was to evaluate survival stratified by the European Society of Cardiology\/European Respiratory Society (ESC\/ERS) baseline risk score, REVEAL risk score 2.0, and etiologies in patients with PAH at high altitudes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted to evaluate functional and hemodynamic variables and risk stratification using the ESC\/ERS baseline risk score and REVEAL risk score 2.0. One-year and five-year survival rates were determined from admission to the pulmonary hypertension program until death or the end of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 188 patients were included. The overall survival rate at one year was 95.8%, and at five years it was 86.8%. Precisely, 50% (95 out of 188) had congenital heart disease, 34% (63 out of 188) had idiopathic, and 13% (24 out of 188) had connective tissue disease. Risk stratification using REVEAL risk score 2.0 classified 58% (109 out of 188) of patients as low risk, 26% as intermediate risk, and 16% (30 out of 188) as high risk. Using the ESC\/ERS baseline risk score, Stratification indicated 78% (146 out of 188) low risk, 21% (40 out of 188) intermediate risk, and 1% (2 out of 188) high risk. High risk according to ESC\/ERS baseline risk score (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and REVEAL risk score 2.0 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) was associated with lower survival. Idiopathic etiology was associated with a lower survival rate (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The survival of patients with PAH at a high-altitude expert center was 95.8% at one year and 86.8% at five years. Risk stratification using the REVEAL risk score 2.0 and the ESC\/ERS baseline risk score was associated with higher mortality in patients classified as high risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251336066","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T13:49:34Z","timestamp":1744724974000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Survival rates at one and five years for patients with group 1 pulmonary arterial hypertension at high altitude: A retrospective cohort study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-3037","authenticated-orcid":false,"given":"Rafael","family":"Conde-Camacho","sequence":"first","affiliation":[{"name":"Department of Pulmonary Hypertension, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogot\u00e1, Colombia"},{"name":"Universidad de La Sabana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-2238","authenticated-orcid":false,"given":"Eduardo","family":"Tuta-Quintero","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8873-9779","authenticated-orcid":false,"given":"Alirio","family":"Bastidas-Goyes","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F","family":"Giraldo-Cadavid","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"},{"name":"Fundaci\u00f3n Neumol\u00f3gica Colombiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Bar\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Hypertension, Fundaci\u00f3n Neumol\u00f3gica Colombiana, Bogot\u00e1, Colombia"},{"name":"Universidad de La Sabana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Mora","sequence":"additional","affiliation":[{"name":"Universidad de La Sabana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1460"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.540"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/681270"},{"key":"e_1_3_5_9_2","first-page":"111","article-title":"Mortality due to idiopathic pulmonary hypertension in Argentina","volume":"10","author":"Mazzei JA","year":"2015","unstructured":"Mazzei JA, C\u00e1neva JO, Khoury M, et al. 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