{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:32:37Z","timestamp":1787063557620,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Scientific Research Fund of Hubei Provincial Health and Family Planning Commission","award":["WJ2015MB088"],"award-info":[{"award-number":["WJ2015MB088"]}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2016CKB709"],"award-info":[{"award-number":["2016CKB709"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Ginsenoside Rg1 has demonstrated beneficial effects in myocardial ischemia-reperfusion (I\/R) injury. However, its potential anti-arrhythmic role in ventricular arrhythmias remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, a whole-cell patch clamp technique was employed to evaluate the effects of Rg1 on L-type calcium current (I\n                      <jats:sub>CaL<\/jats:sub>\n                      ) and ventricular arrhythmia. Western blot analysis was conducted to investigate the underlying signaling pathways involved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ginsenoside Rg1 inhibited I\n                      <jats:sub>CaL<\/jats:sub>\n                      in ventricular myocytes in a concentration-dependent manner. Additionally, Rg1 alleviated the I\/R-induced increase in diastolic intracellular calcium concentration ([Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ]i) and reduced calcium overload. Importantly, Rg1 decreased the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) in I\/R injury models. Mechanistically, these cardioprotective effects appear to be mediated via modulation of the cAMP-PKA and PI3K-AKT signaling pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Rg1 may attenuate the deterioration of cardiac function during acute I\/R injury, lower the susceptibility to ventricular arrhythmias, and prevent their occurrence following I\/R. These findings suggest that Rg1 holds therapeutic potential in the management of I\/R-induced ventricular arrhythmias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251341113","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T03:35:25Z","timestamp":1747971325000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Ginsenoside Rg1 exerts anti-arrhythmic effect by inhibiting I\n                    <sub>CaL<\/sub>\n                    through cAMP-PKA and PI3K-AKT signaling pathways in rat ventricular myocytes after myocardial ischemia-reperfusion injury"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2406-4706","authenticated-orcid":false,"given":"Teng","family":"Wang","sequence":"first","affiliation":[{"name":"Renmin Hospital of Wuhan University"},{"name":"Cardiovascular Research Institute, Wuhan University, Wuhan, PR China"},{"name":"Hubei Key Laboratory of Cardiology, Wuhan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"},{"name":"Cardiovascular Research Institute, Wuhan University, Wuhan, PR China"},{"name":"Hubei Key Laboratory of Cardiology, Wuhan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Chen","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"},{"name":"Cardiovascular Research Institute, Wuhan University, Wuhan, PR China"},{"name":"Hubei Key Laboratory of Cardiology, Wuhan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hubei Provincial Hospital of Traditional Chinese Medicine, Hubei University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cao","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"},{"name":"Cardiovascular Research Institute, Wuhan University, Wuhan, PR China"},{"name":"Hubei Key Laboratory of Cardiology, Wuhan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"},{"name":"Cardiovascular Research Institute, Wuhan University, Wuhan, PR China"},{"name":"Hubei Key Laboratory of Cardiology, Wuhan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Vocational and Technical College of Wuhan University, Wuhan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321668"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20211997"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.10.005"},{"key":"e_1_3_3_7_2","first-page":"213","article-title":"A review of ginseng species in different regions as a multipurpose herb in traditional Chinese medicine, modern herbology and pharmacological science","volume":"13","author":"Shahrajabian MH","year":"2019","unstructured":"Shahrajabian MH, Sun W, Cheng Q. 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