{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:40:39Z","timestamp":1777902039144,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH210"],"award-info":[{"award-number":["ZR2020MH210"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jinan Medical and Health Science and Technology Development Project","award":["202303110816"],"award-info":[{"award-number":["202303110816"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    The necessity of postmastectomy radiotherapy (PMRT) for patients whose initially positive lymph nodes become node-negative (ypN0) after neoadjuvant therapy (NAT) is uncertain. This study analyzed data from the Surveillance, Epidemiology, and End Results database to evaluate PMRT's effect on these patients. Women with unilateral breast cancer who achieved ypN0 status post-NAT from 2010 to 2019 were categorized into PMRT and non-PMRT groups. Propensity score matching (PSM) minimized confounding factors. Statistical tests and multivariate analysis identified survival prognostic factors, while Kaplan-Meier curves and forest plots assessed survival outcomes. The study involved 699 cases, with 458 receiving PMRT and 241 not. After matching, 194 patient pairs were examined. Multivariate analysis revealed stage III disease (hazard ratio: 2.06; 95% CI: 1.12-3.79,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.02) and lack of PMRT (hazard ratio: 2.48; 95% CI: 1.31-4.62,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.01) as independent survival risk factors. PMRT significantly improved overall survival (hazard ratio: 0.43; 95% CI: 0.26-0.72,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001), especially in patients with clinical node status cN+ (cN1, hazard ratio: 0.47; 95%  CI: 0.25-0.88,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.016; cN2-3 hazard ratio: 0.35; 95% CI: 0.15-0.86,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.017, respectively), grade 3 tumors(hazard ratio: 0.47; 95% CI: 0.25-0.88,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.016), stage III disease (hazard ratio: 0.47; 95% CI: 0.26-0.83,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.007), and triplenegative breast cancer (hazard ratio: 0.15; 95% CI: 0.05-0.42,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001). However, it did not significantly benefit those with grade 1-2 tumors, stage II disease, HER2-positive, or hormone receptor-positive\/HER2-negative tumors. The study suggests PMRT may not be necessary for these groups, particularly for HR-positive\/HER2-negative grade 1-2 with stage II disease, due to limited short-term benefits.\n                  <\/jats:p>","DOI":"10.1177\/00368504251344185","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T11:04:32Z","timestamp":1747825472000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Value of postmastectomy radiotherapy on overall survival in stage II\u2013III node-negative patients following neoadjuvant therapy: A surveillance, epidemiology, and end results-based population study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7335-8028","authenticated-orcid":false,"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong Second Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shandong Second Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Oncology, Yantai Laiyang Central Hospital, Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weike","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Hospital affiliated to Shandong First Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Central Hospital affiliated to Shandong First Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33326-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0030"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.8369"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.95"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2019.12.008"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005633"},{"key":"e_1_3_2_10_2","first-page":"22","article-title":"Breast cancer radiotherapy guidelines (2020 edition of the Chinese Medical Doctor Association)","volume":"30","author":"Chinese Medical Doctor Association, Radiation Oncology Physicians Branch","year":"2021","unstructured":"Chinese Medical Doctor Association, Radiation Oncology Physicians Branch; Yexiong L, Yu W, et al. Breast cancer radiotherapy guidelines (2020 edition of the Chinese Medical Doctor Association). Chin J Radiat Oncol 2021; 30: 22.","journal-title":"Chin J Radiat Oncol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.12.054"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.12.009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.129"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.09.056"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw046"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2017.07.051"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07249-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-022-00609-8"},{"key":"e_1_3_2_19_2","first-page":"6632635","article-title":"Impact of postmastectomy radiotherapy on locoregional control and disease-free survival in patients with breast cancer treated with neoadjuvant chemotherapy","volume":"2021","author":"Zhang Y","year":"2021","unstructured":"Zhang Y, Zhang Y, Liu Z, et al. Impact of postmastectomy radiotherapy on locoregional control and disease-free survival in patients with breast cancer treated with neoadjuvant chemotherapy. 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