{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:28:28Z","timestamp":1793208508290,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulpotomy is widely used in primary and immature permanent teeth, but its effectiveness in mature permanent teeth with irreversible pulpitis remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify and evaluate the existing systematic reviews of randomized controlled trials (RCTs) assessing pulpotomy as a treatment for irreversible pulpitis in mature permanent teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A protocol-guided search was conducted across PubMed, ProQuest, EMBASE, and Cochrane up to March 2024, targeting systematic reviews based on RCTs. Eligibility, selection, data extraction, and risk of bias assessment were performed independently by two reviewers. Quality was assessed using the AMSTAR 2 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 52 articles retrieved, only one systematic review met inclusion criteria. The review included four RCTs involving 874 patients. Reported clinical success rates ranged from 81.2% to 98.19%, and radiographic success ranged from 38.4% to 95%, with the highest outcomes observed for calcium-enriched mixture and mineral trioxide aggregate. The AMSTAR 2 assessment rated the systematic review as critically low quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence from systematic reviews is insufficient to definitively recommend pulpotomy for irreversible pulpitis in mature permanent teeth. However, favorable clinical outcomes and the minimally invasive, cost-effective nature of the procedure suggest that pulpotomy may serve as a practical alternative to root canal treatment in select cases. High-quality RCTs and systematic reviews are urgently needed to strengthen the evidence base.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251346677","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T03:15:34Z","timestamp":1748315734000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Pulpotomy for irreversible pulpitis in mature permanent teeth: An overview of systematic reviews of randomized controlled trials"],"prefix":"10.1177","volume":"108","author":[{"given":"Ajay","family":"Chhabra","sequence":"first","affiliation":[{"name":"Department of Dentistry, AIIMS Kalyani, Kalyani, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4866-6655","authenticated-orcid":false,"given":"B Saravana","family":"Prathap","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, AIIMS Kalyani, Kalyani, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"KP","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, AIIMS Kalyani, Kalyani, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, AIIMS Kalyani, Kalyani, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Himani","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, AIIMS Kalyani, Kalyani, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona J","family":"Parvathy","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, AIIMS Kalyani, Kalyani, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Department of Dentistry, H.S. Judge Dental College Panjab University, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/children10091447"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.02.030"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12605"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2021.07.015"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13080"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2019.06.005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-1003-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9060720"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20918-w"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12614"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12903"},{"key":"e_1_3_3_13_2","article-title":"Effectiveness of pulpotomy procedures in mature permanent teeth with irreversible pulpitis","volume":"7","author":"Robledo JG","year":"2023","unstructured":"Robledo JG, Rodriguez PA. Effectiveness of pulpotomy procedures in mature permanent teeth with irreversible pulpitis. J Oral Dent Health 2023 [cited 2025 May 3]; 7. https:\/\/www.opastpublishers.com\/open-access-articles\/effectiveness-of-pulpotomy-procedures-in-mature-permanent-teeth-with-irreversible-pulpits.pdf.","journal-title":"J Oral Dent Health"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-022-5316-1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ebd.6400636"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-070849","article-title":"Reporting guideline for overviews of reviews of healthcare interventions: development of the PRIOR statement","volume":"378","author":"Gates M","year":"2022","unstructured":"Gates M, Gates A, Pieper D, et al. Reporting guideline for overviews of reviews of healthcare interventions: development of the PRIOR statement. Br Med J 2022; 378: e070849.","journal-title":"Br Med J"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12694"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2015.12.005"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.104923"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4103\/JCD.JCD_179_19"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57060573"},{"key":"e_1_3_3_22_2","first-page":"23","article-title":"Health technology assessment of CEM pulpotomy in permanent molars with irreversible pulpitis","volume":"9","author":"Yazdani S","year":"2014","unstructured":"Yazdani S, Jadidfard MP, Tahani B, et al. Health technology assessment of CEM pulpotomy in permanent molars with irreversible pulpitis. Iran Endod J 2014; 9: 23\u201329.","journal-title":"Iran Endod J"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2014.06.007"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.12.004"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500204"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/960321"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2015.06.010"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.10.027"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.01.018"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/etp.12019"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.08.010"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251346677","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504251346677","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504251346677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:16:17Z","timestamp":1777634177000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504251346677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1177\/00368504251346677"],"URL":"https:\/\/doi.org\/10.1177\/00368504251346677","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"article-number":"00368504251346677"}}