{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:40:05Z","timestamp":1777902005271,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>There is crosstalk between the thyroid hormone and the renin-angiotensin-aldosterone system, but the clinical application is lacking. Our study aimed to verify the correlation between renin and other thyroid-related biomarkers and their association with treatment prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study recruited eighty consecutive patients treated for hyperthyroidism in a medical center between 2021 and 2023. Among participants, 53 were newly diagnosed, and 27 were recurrent cases. Laboratory measurements, including renin, aldosterone, and other thyroid-related biomarkers, were assessed, while the associations of biomarkers and clinical symptoms were also analyzed. The clinical variables and biomarkers were entered into the Cox regression model to identify the independent risks associated with time to achieve euthyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The correlation matrix showed that free T4 was positively correlated either with T3 (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.755,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) or renin (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.341,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.002) but not with aldosterone (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.055,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.631). In ROC analysis for biomarkers and clinical symptoms, either free T4 (AUC\u2009=\u20090.754,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) or thyroid-stimulating hormone receptor antibody (TSHRAb) (AUC\u2009=\u20090.645,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.026) demonstrated effective prediction of tachycardia; however, renin was slightly positive for tachycardia without significance (AUC\u2009=\u20090.580,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.233). Regarding thyrotoxic periodic paralysis, the renin showed significant prediction power (AUC\u2009=\u20090.727.\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.021) rather than free T4 (AUC\u2009=\u20090.543,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.748) or TSHRAb (AUC\u2009=\u20090.688,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.063). The median time to achieve euthyroidism was 166 days for newly onset patients and 216 days for recurrence, but the time-to-event curves showed no difference (log rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.728). Under Cox regression modeling, TSHRAb was found to independently predict late euthyroidism (Hazard ratio 0.946, 95% confidence interval 0.901\u20130.993,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.026), and the renin had no impact (HR 0.995, 95% CI 0.987\u20131.003,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.215).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Renin but not aldosterone was positively correlated with free T4. Certain biomarkers measured at diagnosis were associated with hyperthyroid symptoms. Free T4 and TSHRAb might predict tachycardia, while renin might predict thyrotoxic periodic paralysis; nevertheless, only higher TSHRAb was associated with delayed euthyroid state achievement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251346842","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:02:49Z","timestamp":1748318569000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between renin and thyroid-related biomarkers with clinical characteristics and outcomes in hyperthyroid patients"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4560-2869","authenticated-orcid":false,"given":"Han-Yun","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital at Linkou, Taoyuan City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-6417","authenticated-orcid":false,"given":"I-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital at Linkou, Taoyuan City"},{"name":"Chang Gung University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-7030","authenticated-orcid":false,"given":"Cheng-Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital at Linkou, Taoyuan City"},{"name":"Chang Gung University"},{"name":"National Tsing Hua University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406163302407"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19052"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00521"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.678326"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409293311306"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.10.8828482"},{"key":"e_1_3_5_8_2","first-page":"139","article-title":"Thyroid hormone and the cardiovascular system","volume":"29","author":"Danzi S","year":"2004","unstructured":"Danzi S, Klein I. 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