{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:40:53Z","timestamp":1777902053340,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Gastrointestinal diseases are common, yet some countries still lack endoscopy. Modern flexible endoscopy was introduced to the Solomon Islands National Referral Hospital (NRH) in 2012, but little is known about gastrointestinal disease in the country.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study describes trends in upper gastrointestinal diseases to inform local research and health programming. Demographic, clinical, and endoscopic data, including rapid urease test (RUT) results for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      , were abstracted from consecutively entered patient medical records at the NRH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 761 patients underwent upper endoscopy and RUT (2019\u20132022). Although RUT was positive in only 25.8% of patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009196), relatively common findings of erosions (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200990, 11.8%) and ulcers (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200989, 11.7%), as well as frequently reported symptoms of upper gastrointestinal bleeding (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009168, 22.1%), suggest a higher true prevalence of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -associated peptic ulcer disease in this cohort. Age was associated with an endoscopic finding of ulcers on univariate analysis. Multivariable modeling indicated a significant association between the presence of gastric erythema and erosions and the diagnosis of duodenitis. Multivariable regression also showed symptoms of melena and hematemesis to be significantly associated with the endoscopic finding of ulcers. Among patients treated for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      who underwent follow-up endoscopy and RUT, 28.8% failed treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was a high degree of concern regarding gastrointestinal symptomology and pathology in this cohort. Access to endoscopy and RUT in Solomon Islands remains limited to a single endoscopy unit. Future efforts should explore non-invasive clinical pathways for the expansion of RUT and the management of ulcer disease in Solomon Islands.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251355383","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T12:12:59Z","timestamp":1756123979000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Upper endoscopy in Solomon Islands: A four-year retrospective study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-7367","authenticated-orcid":false,"given":"Dylan M","family":"Bush","sequence":"first","affiliation":[{"name":"Division of Biology and Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stallone","family":"Kohia","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Papua New Guinea, Port Moresby, New Guinea"},{"name":"National Referral Hospital, Solomon Islands Ministry of Health and Medical Services, Honiara, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Garcia Hernandez","sequence":"additional","affiliation":[{"name":"Data Science Institute, Fu Foundation School of Engineering and Applied Science, Columbia University, New York City, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Siota","sequence":"additional","affiliation":[{"name":"National Referral Hospital, Solomon Islands Ministry of Health and Medical Services, Honiara, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Wore","sequence":"additional","affiliation":[{"name":"National Referral Hospital, Solomon Islands Ministry of Health and Medical Services, Honiara, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rooney","family":"Jagilly","sequence":"additional","affiliation":[{"name":"National Referral Hospital, Solomon Islands Ministry of Health and Medical Services, Honiara, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augustin","family":"Melly","sequence":"additional","affiliation":[{"name":"National Referral Hospital, Solomon Islands Ministry of Health and Medical Services, Honiara, Solomon Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H","family":"Katelaris","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Concord Hospital, University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W","family":"Norrie","sequence":"additional","affiliation":[{"name":"Solomon Islands Program, Australia New Zealand Gastroenterology Training Association, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-8206","authenticated-orcid":false,"given":"Alexandra LC","family":"Martiniuk","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Public Health, The University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3447-0388","authenticated-orcid":false,"given":"Steven F","family":"Moss","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, The Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.05.050"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30488-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.10.022"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.086371"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2839"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02184"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/11786329211020857"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1787\/c7467f62-en"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19169815"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2022.03.002"},{"key":"e_1_3_2_12_2","first-page":"9","article-title":"Diagnosis of Helicobacter pylori using the rapid urease test","volume":"3","author":"Uotani T","year":"2015","unstructured":"Uotani T, Graham DY. 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