{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:40:10Z","timestamp":1777902010925,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"SNUH Lee Kun-hee Child Cancer & Rare Disease Project","award":["23C-023-0100"],"award-info":[{"award-number":["23C-023-0100"]}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2023IP0094\u20101"],"award-info":[{"award-number":["2023IP0094\u20101"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Recent advancements in high-resolution ultrasonography (US) have established it as a critical tool for evaluating parotid lesions. However, the lack of standardized diagnostic criteria limits the utility of US in determining malignancy. This study investigates the potential role of US as a prognostic factor in parotid cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients diagnosed with and surgically treated for parotid cancer at our tertiary referral center from January 2016 to December 2022 were included in this retrospective cohort study. We retrospectively obtained patient data including US images and clinical factors and analyzed their correlation with various adverse features and oncological outcomes, including five-year disease-free survival (5Y DFS) and overall survival (5Y OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 126 patients were included. The 5Y DFS and 5Y OS were 81.7%\u2009\u00b1\u20093.7% and 81.2%\u2009\u00b1\u20094.1% respectively. Multivariate analysis revealed that age (DFS; HR 2.75 [1.76\u20134.29],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.023, OS; HR 3.38 [2.06\u20135.54],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.014), clinical nodal stage (DFS; HR 5.87 [3.74\u20139.21],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001, OS; HR 9.34 [5.48\u201315.91],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and the presence of posterior enhancement artifact on US (DFS; HR 0.33 [0.21\u20130.53],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.019, OS; HR 0.34 [0.20\u20130.57],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.037) were significant variables. In patients with early-stage parotid cancer who showed posterior enhancement, the extent of surgery did not affect treatment outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Posterior acoustic enhancement on ultrasonography is a favorable prognostic factor in parotid cancer. For patients with early-stage cancer who demonstrate posterior enhancement, minimizing the extent of surgery does not compromise oncologic outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504251356179","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T04:01:29Z","timestamp":1751342489000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasonographic findings as a prognostic factor in parotid cancer"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-7082","authenticated-orcid":false,"given":"Jeong Heon","family":"Kim","sequence":"first","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Ho","family":"Woo","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minsu","family":"Kwon","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3399-8167","authenticated-orcid":false,"given":"Young Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6534-5753","authenticated-orcid":false,"given":"Yoon Se","family":"Lee","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1742271X15626611"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13137"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815607449"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2018.00039"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870230067009"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.10.009"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5122-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2015.10.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104780"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2010.01.009"},{"key":"e_1_3_3_12_2","first-page":"194","article-title":"Ultrasonography techniques in the preoperative diagnosis of parotid gland tumors - an updated review of the literature","volume":"23","author":"Stoia S","year":"2021","unstructured":"Stoia S, Baciut G, Lenghel M, et al. 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